In silicoanalysis of protein/peptide-based inhalers against SARS-CoV-2

被引：3
|
作者：
Salman, Saad [1 ]
Shah, Fahad Hassan [2 ]
Chaudhry, Maham [1 ]
Tariq, Muniba [3 ]
Akbar, Muhammad Yasir [4 ]
Adnan, Muhammad [1 ]
机构：
[1] Univ Lahore, Dept Pharm, Islamabad Campus, Islamabad 44000, Federal, Pakistan
[2] Univ Peshawar, Ctr Biotechnol & Microbiol, Khyber Pakhtunkhwa, Pakistan
[3] Univ Lahore, Diet & Nutr Sci, Islamabad Campus, Islamabad 44000, Federal, Pakistan
[4] Quaid i Azam Univ, Dept Bioinformat, Islamabad 44000, Federal, Pakistan
来源：
FUTURE VIROLOGY | 2020年 / 15卷 / 09期
关键词：
COVID-19; dornase-alfa; inhalers; monoclonal antibody; short-palate-lung and nasal-epithelial clone-1-derived peptides; DELIVERY; LUNG;
D O I：
10.2217/fvl-2020-0119
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim:Peptide/protein-based inhalers are excessively used to treat respiratory disorders. The molecular docking was performed for these inhalers including human neutralizing S230 light chain-antibody (monoclonal antibodies [mAbs]), alpha-1-antitrypsin (AAT), short-palate-lung and nasal-epithelial clone-1-derived peptides (SPLUNC1) and dornase-alfa (DA) against spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to assess their inhibitory activity.Materials & methods:HawkDock was used to dock these biologics against SARS-CoV-2 spike-glycoprotein.Results:Results showed that DA, AAT and mAb were quite active against spike glycoprotein with a binding free energy of -26.35 and -22.94 kcal/mol.Conclusion:mAB and AAT combined with DA can be used in the treatment of coronavirus disease of 2019 as a potential anti-SARS-CoV-2 agent.
引用
收藏
页码：557 / 564
页数：8
相关论文
共 50 条
  • [1] Peptide-Based Inhibitors for SARS-CoV-2 and SARS-CoV
    Panchal, Disha
    Kataria, Jeena
    Patel, Kamiya
    Crowe, Kaytlyn
    Pai, Varun
    Azizogli, Abdul-Rahman
    Kadian, Neil
    Sanyal, Sreya
    Roy, Abhishek
    Dodd-o, Joseph
    Acevedo-Jake, Amanda M.
    Kumar, Vivek A.
    ADVANCED THERAPEUTICS, 2021, 4 (10)
  • [2] Peptide and peptide-based inhibitors of SARS-CoV-2 entry
    Schuetz, Desiree
    Ruiz-Blanco, Yasser B.
    Muench, Jan
    Kirchhoff, Frank
    Sanchez-Garcia, Elsa
    Mueller, Janis A.
    ADVANCED DRUG DELIVERY REVIEWS, 2020, 167 : 47 - 65
  • [3] The potential of developing a protective peptide-based vaccines against SARS-CoV-2
    Shalash, Ahmed O.
    Toth, Istvan
    Skwarczynski, Mariusz
    DRUG DEVELOPMENT RESEARCH, 2022, 83 (06) : 1251 - 1256
  • [4] A strategy to optimize the peptide-based inhibitors against different mutants of the spike protein of SARS-CoV-2
    Priya, Prerna
    Basit, Abdul
    Bandyopadhyay, Pradipta
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, 41 (13): : 6191 - 6202
  • [5] Potential Role of Peptide-Based Antiviral Therapy Against SARS-CoV-2 Infection
    Maiti, Biplab K.
    ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2020, 3 (04) : 783 - 785
  • [6] Development of multi-epitope peptide-based vaccines against SARS-CoV-2
    Lim, Hui Xuan
    Lim, Jianhua
    Jazayeri, Seyed Davoud
    Poppema, Sibrandes
    Poh, Chit Laa
    BIOMEDICAL JOURNAL, 2021, 44 (01) : 18 - 30
  • [7] Evaluation of Potential Peptide-Based Inhibitors against SARS-CoV-2 and Variants of Concern
    Boshah, Hattan
    Samkari, Faris
    Valle-Perez, Alexander U.
    Alsawaf, Sarah M.
    Aldoukhi, Ali H.
    Bilalis, Panayiotis
    Alshehri, Salwa A.
    Susapto, Hepi H.
    Hauser, Charlotte A. E.
    BIOMED RESEARCH INTERNATIONAL, 2023, 2023
  • [8] Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2
    Kalita, Parismita
    Padhi, Aditya K.
    Zhang, Kam Y. J.
    Tripathi, Timir
    MICROBIAL PATHOGENESIS, 2020, 145
  • [9] A Novel Peptide-Based Detection of SARS-CoV-2 Antibodies
    Bulut, Aliye
    Temur, Betul Z.
    Kirimli, Ceyhun E.
    Gok, Ozgul
    Balcioglu, Bertan K.
    Ozturk, Hasan U.
    Uyar, Neval Y.
    Kanlidere, Zeynep
    Kocagoz, Tanil
    Can, Ozge
    BIOMIMETICS, 2023, 8 (01)
  • [10] Peptide-Based Vaccine against SARS-CoV-2: Peptide Antigen Discovery and Screening of Adjuvant Systems
    Shalash, Ahmed O.
    Azuar, Armira
    Madge, Harrison Y. R.
    Modhiran, Naphak
    Amarilla, Alberto A.
    Liang, Benjamin
    Khromykh, Alexander A.
    Hussein, Waleed M.
    Chappell, Keith J.
    Watterson, Daniel
    Young, Paul R.
    Skwarczynski, Mariusz
    Toth, Istvan
    PHARMACEUTICS, 2022, 14 (04)
12345