A facile microwave assisted synthesis of spiro-1,3-oxazines from N-(2-(cyclohex-1-en-1-yl)ethyl)amides

被引：12
|
作者：
Saikia, Ujwal Pratim [1 ]
Baruah, Diganta [1 ]
Pahari, Pallab [1 ]
Borah, Manash Jyoti [1 ]
Goswami, Amrit [1 ]
Konwar, Dilip [1 ]
机构：
[1] CSIR North East Inst Sci & Technol, Synthet Organ Chem Div, Jorhat 785006, Assam, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 31期
关键词：
Spiroxazine; Microwave assisted synthesis; Trimethylsilyl iodide; DIASTEREOSELECTIVE SYNTHESIS; DERIVATIVES; 2-OXAZOLINES; OXAZOLINES; CONVERSION; CARBAMATE; ALDEHYDES; OXAZINES; AGENTS; SPIRO;
D O I：
10.1016/j.tetlet.2014.06.042
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild and efficient methodology has been developed for the synthesis of spiro-1,3-oxazine derivatives by the microwave assisted cyclization of N-2-(1'-cyclohexenyl)ethyl-acetamides/benzamides. The reaction was catalyzed by in situ generated trimethylsilyl iodide and featured by its very short reaction time. The starting materials were easily obtained by the condensation of substituted acetic/benzoic acids with 2-(1'-cyclohexenyl)ethyl amine. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4328 / 4330
页数：3
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