Oxidative stress-mediated myrocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats

被引：9
|
作者：
Saracoglu, Ahmet [1 ]
Temel, Halide E. [2 ]
Ergun, Buelent [1 ]
Colak, Oemer [3 ]
机构：
[1] Anadolu Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-25470 Eskisehir, Turkey
[2] Anadolu Univ, Dept Biochem, Fac Pharm, TR-25470 Eskisehir, Turkey
[3] Osmangazi Univ, Fac Med, Dept Biochem, Eskisehir, Turkey
来源：
DRUG AND CHEMICAL TOXICOLOGY | 2009年 / 32卷 / 03期
关键词：
Fluoroquinolones; cardiotoxicity; oxidative stress; FLUOROQUINOLONES; TOXICITY; SERUM;
D O I：
10.1080/01480540902882176
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were administered to the rats for 1 week. Serum biochemical cardiotoxicity parameters and tissue malondialdehyde and nitric oxide levels were measured. All measured parameters were found elevated in the drug-treated rats, being the highest in the 50-mg/kg ofloxacin-treated rats. Ciprofloxacin and ofloxacin may cause myocardiotoxicity by inducing the oxidative stress in the heart, and nitric oxide is partly responsible for this toxicity.
引用
收藏
页码：238 / 242
页数：5
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