Metformin is associated with reduced risk of pancreatic cancer in patients with type 2 diabetes mellitus: A systematic review and meta-analysis

被引:140
|
作者
Wang, Zheng [1 ,3 ]
Lai, Song-tao [1 ,3 ]
Xie, Li [2 ,3 ]
Zhao, Jian-dong [1 ,3 ]
Ma, Ning-yi [1 ,3 ]
Zhu, Ji [1 ,2 ,3 ]
Ren, Zhi-gang [1 ,3 ]
Jiang, Guo-liang [1 ,3 ]
机构
[1] Fudan Univ, Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Canc Ctr, Dept Stat, Shanghai 200032, Peoples R China
[3] Fudan Univ, Shanghai Canc Ctr, Dept Oncol, Shanghai 200032, Peoples R China
关键词
Metformin; Diabetes mellitus; Pancreatic cancer; Meta-analysis; LUNG-CANCER; COHORT; CELLS; THERAPY; GROWTH; PROLIFERATION; GEMCITABINE; INHIBITION; APOPTOSIS; DIAGNOSIS;
D O I
10.1016/j.diabres.2014.04.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims: Recent epidemiological studies indicated that use of metformin might decrease the risk of various cancers among patients with type 2 diabetes mellitus (T2DM). However, its influence on pancreatic cancer was controversial. Therefore, we did a meta-analysis of currently available observational studies on the issue. Methods: We did a PubMed and ISI Web of Science search for observational articles. The pooled relative risk (RR) was estimated using a random-effect model. Heterogeneity was evaluated using I-2 statistic. Subgroup analysis was performed to explore the source of heterogeneity and confirm the overall estimates. Publication bias was also examined. Results: The analysis included 11 articles (13 studies) comprising 10 cohort studies and 3 case-control studies. Use of metformin was associated with a significant lower risk of pancreatic cancer [RR 0.63, 95% confidence internal (CI) 0.46-0.86, p = 0.003]. In a total 11 subgroup analyses, 5 provided the consistent result with pooled effect estimates of overall analysis. No publication bias was detected by Begg's (Z = -0.79, p = 0.428) and Egger's test (t = -0.92, p = 0.378). Conclusions: From present observational studies, use of metformin appears to be associated with a reduced risk of pancreatic cancer in patients with T2DM. Further investigation is needed. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:19 / 26
页数:8
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