Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease

被引：42

作者：

Fung, Hon-Chung

Chen, Chiung-Mei

Hardy, John

Hernandez, Dena

Singleton, Andrew

Wu, Yih-Ru

机构：

[1] Chang Gung Mem Hosp, Dept Neurol, Taipei 10591, Taiwan

[2] NIA, Neurogenet Lab, Bethesda, MD USA

[3] UCL, Reta Lila Weston Inst Neurol Studies, London, England

[4] Chang Gung Univ, Coll Med, Taipei, Taiwan

来源：

MOVEMENT DISORDERS | 2006年 / 21卷 / 06期

基金：

英国医学研究理事会;

关键词：

LRRK2; Parkinson's disease; Taiwan; mutation;

D O I：

10.1002/mds.20814

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G > A, which produces a glycine-to-serine amino acid substitution at codon 2019 in idiopathic Taiwanese PD. The extreme rarity of the G2019S mutation in our population suggests the occurrence of this mutation resulted from a common European founder. (c) 2006 Movement Disorder Society.

引用

页码：880 / 881

页数：2

共 50 条

[1] G2019S LRRK2 mutation in familial and sporadic Parkinson's disease in Russia
Pchelina, Sofya N.
Yakimovskii, Andrei F.
Ivanova, Olga N.
Emelianov, Anton K.
Zakharchuk, Andrei H.
Schwarzman, Alexander L.
[J]. MOVEMENT DISORDERS, 2006, 21 (12) : 2234 - 2236
[2] LRRK2 G2019S Mutation in an Argentinean Cohort of Patients with Parkinson's Disease
Gatto, Emilia M.
Converso, Daniela P.
Marti-Masso, Jose F.
Sebastian, San
Ruiz, Coro Paisan
Persi, Gabriel
Etcheverry, Jose L.
Parisi, Virginia
Leiguarda, Fernando
Carreras, Maria C.
Poderoso, Juan J.
[J]. NEUROLOGY, 2010, 74 (09) : A253 - A253
[3] Investigation of LRRK2 G2019S Mutation in the Patients with Sporadic Parkinson's Disease in Turkey
Aslan, Huseyin
Ozkan, Serhat
Tepeli, Emre
Emre, Ramazan
Kutlay, Ozden
Gurler, Abdullah Ihsan
Uludag, Ahmet
Muslumanoglu, M. Hamza
[J]. KONURALP TIP DERGISI, 2014, 6 (01): : 1 - 4
[4] DEEP PHENOTYPING OF THE G2019S LRRK2 MUTATION IN PARKINSON'S DISEASE: UCL COHORT
Rizig, Mie
Jonvik, Hallgeir
Foltynie, Thomas
Limousin, Patricia
Bhatia, Kailash
Warner, Thomas
Morris, Huw
Wood, Nicholas
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2016, 87 (12):
[5] The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients
Tan, EK
Shen, H
Tan, LCS
Farrer, A
Yew, K
Chua, E
Jamora, RD
Puvan, K
Puong, KY
Zhao, Y
Pavanni, R
Wong, MC
Yih, Y
Skipper, L
Liu, JJ
[J]. NEUROSCIENCE LETTERS, 2005, 384 (03) : 327 - 329
[6] The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease
Kalinderi, K.
Fidani, L.
Bostantjopoulou, S.
Katsarou, Z.
Kotsis, A.
[J]. EUROPEAN JOURNAL OF NEUROLOGY, 2007, 14 (10) : 1088 - 1090
[7] Frequency of the LRRK2 G2019S mutation in siblings with Parkinson's disease
Lesage, Suzanne
Leclere, Laurence
Lohmann, Ebba
Borg, Michel
Ruberg, Merle
Duerr, Alexandra
Brice, Alexis
[J]. NEURODEGENERATIVE DISEASES, 2007, 4 (2-3) : 195 - 198
[8] LRRK2 mRNA and protein expression in Parkinson's disease cases with LRRK2 G2019S mutation
Sharma, S.
Bandopadhyay, R.
Kingsbury, A. E.
Lashley, T. C.
Lees, A. J.
Revesz, T.
Wood, N. W.
Holton, J. L.
[J]. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2009, 35 : 27 - 28
[9] The G2019S LRRK2 mutation in a Brazilian cohort with Parkinson's disease: Phenotype in monozygotic twins
Munhoz, Renato
Teive, Helio
Werneck, Lineu
Raskin, Salmo
Sato, Christine
Moreno, Danielle
Rogaeva, Ekaterina
[J]. NEUROLOGY, 2008, 70 (11) : A291 - A291
[10] Frequency of the LRRK2 G2019S mutation in late-onset sporadic patients with Parkinson's disease
Chien, Hsin Fen
Figueiredo, Tamires Rocha
Hollaender, Marianna Almeida
Tofoli, Fabiano
Takada, Leonel Tadao
Pereira, Lygia do Veiga
Barbosa, Egberto Reis
[J]. ARQUIVOS DE NEURO-PSIQUIATRIA, 2014, 72 (05) : 356 - 359

← 1 2 3 4 5 →