Side-modified 15-deoxy-Δ12,14-prostaglandin D2, precursor of corresponding PGJ2. Synthesis from cloprostenol and anticancer activity

被引：9
|
作者：
Vostrikov, Nikolay S. [1 ]
Lobko, Ilya F. [1 ]
Spirikhin, Leonid V. [1 ]
Vakhitova, Yulia V. [2 ]
Pivnitsky, Kasimir K. [3 ]
Miftakhov, Mansur S. [1 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, Ufa 450054, Russia
[2] Russian Acad Sci, Ufa Sci Ctr, Inst Biochem & Genet, Ufa 450054, Russia
[3] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia
来源：
MENDELEEV COMMUNICATIONS | 2017年 / 27卷 / 02期
关键词：
CYCLOPENTENONE PROSTAGLANDINS; PHASE SYNTHESIS; METHYL-ESTER; PC12; CELLS; KAPPA-B; J(2); ANTITUMOR; DERIVATIVES; GROWTH; A(1);
D O I：
10.1016/j.mencom.2017.03.005
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The title compound, a possible precursor of metabolically stable corresponding PGJ(2), was obtained from cloprostenol in seven steps. The compound demonstrated cytotoxicity against the HEK 293, Hep G2 and Jurkat cell lines.
引用
收藏
页码：125 / 127
页数：3
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