Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering

被引：74

作者：

Cho, Changhee ^{[1
,2
,3
]}

Choi, So Young ^{[1
,2
,3
]}

Luo, Zi Wei ^{[1
,2
,3
]}

Lee, Sang Yup ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Plus Program BK21, Metab & Biomol Engn Natl Res Lab, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Ctr Syst & Synthet Biotechnol, Taejon 305701, South Korea

[3] Korea Adv Inst Sci & Technol, Inst BioCentury, Taejon 305701, South Korea

[4] Korea Adv Inst Sci & Technol, BioInformat Res Ctr, Taejon 305701, South Korea

[5] Korea Adv Inst Sci & Technol, BioProc Engn Res Ctr, Taejon 305701, South Korea

[6] Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, Horsholm, Denmark

来源：

BIOTECHNOLOGY ADVANCES | 2015年 / 33卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Systems metabolic engineering; Fuels; Building block chemicals; Specialty chemicals; 3-HYDROXYPROPIONIC ACID PRODUCTION; ESCHERICHIA-COLI STRAIN; HIGH-YIELD PRODUCTION; L-TYROSINE PRODUCTION; SACCHAROMYCES-CEREVISIAE; FATTY-ACID; SUCCINIC ACID; LACTIC-ACID; MANNHEIMIA-SUCCINICIPRODUCENS; CLOSTRIDIUM-ACETOBUTYLICUM;

D O I：

10.1016/j.biotechadv.2014.11.006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The advent of various systems metabolic engineering tools and strategies has enabled more sophisticated engineering of microorganisms for the production of industrially useful fuels and chemicals. Advances in systems metabolic engineering have been made in overproducing natural chemicals and producing novel non-natural chemicals. In this paper, we review the tools and strategies of systems metabolic engineering employed for the development of microorganisms for the production of various industrially useful chemicals belonging to fuels, building block chemicals, and specialty chemicals, in particular focusing on those reported in the last three years. It was aimed at providing the current landscape of systems metabolic engineering and suggesting directions to address future challenges towards successfully establishing processes for the bio-based production of fuels and chemicals from renewable resources. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：1455 / 1466

页数：12

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