A Radical Signal Activates the Epigenetic Regulation of Longevity

被引：10
|
作者：
Mirisola, Mario G. [1 ,2 ,3 ]
Longo, Valter D. [2 ,3 ]
机构：
[1] Univ Palermo, Dept Med & Forens Biotechnol DiBiMeF, I-90133 Palermo, Italy
[2] Univ So Calif, Sch Gerontol, Longev Inst, Los Angeles, CA 90089 USA
[3] Univ So Calif, Dept Biol Sci, Los Angeles, CA 90089 USA
来源：
CELL METABOLISM | 2013年 / 17卷 / 06期
关键词：
CHRONOLOGICAL LIFE-SPAN; YEAST; EXTENSION; SCH9;
D O I：
10.1016/j.cmet.2013.05.015
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.
引用
收藏
页码：812 / 813
页数：2
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