The sequencing-based typing tool of dbMHC: typing highly polymorphic gene sequences

被引：31
|
作者：
Helmberg, W [1 ]
Dunivin, R [1 ]
Feolo, M [1 ]
机构：
[1] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA
来源：
NUCLEIC ACIDS RESEARCH | 2004年 / 32卷
关键词：
D O I：
10.1093/nar/gkh424
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The dbMHC resource (http://www.ncbi.nlm.nih.gov/mhc/sbt.cgi?cmd=main) at the National Center for Biotechnology Information (NCBI) has developed an online tool for evaluating the allelic composition of sequencing-based typing (SBT) results of cDNA or genomic sequences. Whether the samples are heterozygous, haploid or a combination of the two, they can be compared with two up-to-date databases of all known alleles of several human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptor (KIR) loci. The results of the submission are returned as a table of potential allele hits, along with the respective base changes and an interactive sequence viewer for close examination of the alignment.
引用
收藏
页码：W173 / W175
页数：3
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