Catastrophic antiphospholipid syndrome

The catastrophic antiphospholipid syndrome is a potentially life-threatening condition with a high mortality, which requires a high degree of clinical awareness on the part of attending physicians. Patients with this syndrome have in common: clinical evidence of multiple organ involvement developed over a very short time period; histopathologic evidence of multiple small vessel occlusions; and laboratory confirmation of the presence of antiphospholipid antibodies, usually in high titer. The combination of high doses of intravenous (iv) heparin, iv steroids, iv gammaglobulins, or repeated plasma exchanges is the basic treatment of choice for all patients with this severe condition.