New developments in immunosuppressive therapy for heart transplantation

被引：0

作者：

Khush, Kiran K. ^{[1
]}

Valantine, Hannah A. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA

来源：

EXPERT OPINION ON EMERGING DRUGS | 2009年 / 14卷 / 01期

关键词：

acute rejection; AEB071; alefacept; alemtuzumab; antibody-mediated rejection; antiproliferative agents; antithymocyte globulin; atacicept; azathioprine; basiliximab; belatacept; belimumab; bortezomib; calcineurin inhibitor; cardiac allograft vasculopathy; cellular rejection; chronic rejection; ciclosporin; corticosteroids; CP-690550; daclizumab; efalizumab; epratuzumab; everolimus; FK778; FTY720; heart transplant; immunosuppressant drugs; induction regimen; ISA247; JAK-3; inhibitor; KRP203; monoclonal antibodies; muromonab; mycophenolate mofetil; OKT3; polyclonal antibodies; proliferation signal inhibitors; rapamycin; sirolimus; tacrolimus; voclosporin; CARDIAC ALLOGRAFT VASCULOPATHY; RABBIT ANTITHYMOCYTE GLOBULIN; COATED MYCOPHENOLATE SODIUM; CORONARY-ARTERY-DISEASE; CONVERTING ENZYME-INHIBITORS; INTRAVENOUS IMMUNE GLOBULIN; SOLID-ORGAN TRANSPLANTATION; RANDOMIZED CONTROLLED-TRIAL; NOVO RENAL-TRANSPLANTATION; DE-NOVO;

D O I：

10.1517/14728210902791605

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Heart transplantation is a well-established therapeutic option for many patients with end-stage heart disease. A major challenge in heart transplantation today is providing effective immunosuppression to prevent graft rejection while minimizing the many adverse effects of currently available therapies. Objective: To systematically review current immunosuppressive treatment strategies after heart transplantation and to review emerging drugs in various stages of development. Methods: A comprehensive literature review was performed using the online PubMed and Pharmaprojects; databases. Results/conclusions: This article gives an overview of the immunosuppressive agents in current use, with a detailed review of emerging drugs with novel therapeutic targets.

引用

页码：1 / 21

页数：21

共 50 条

[1] New developments in immunosuppressive therapy in renal transplantation
Gourishankar, S
Turner, P
Halloran, P
[J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2002, 2 (05) : 483 - 501
[2] Advances of immunosuppressive therapy for heart transplantation
Lietz, Katherine
[J]. KARDIOCHIRURGIA I TORAKOCHIRURGIA POLSKA-POLISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2005, 2 (04) : 18 - 22
[3] New immunosuppressive drugs in heart transplantation
Costanzo, MR
[J]. CURRENT CONTROLLED TRIALS IN CARDIOVASCULAR MEDICINE, 2001, 2 (01): : 45 - 53
[4] New immunosuppressive drugs in heart transplantation
Maria Rosa Costanzo
[J]. Current Controlled Trials in Cardiovascular Medicine, 2001, 2 (1):
[5] Osteoporosis following heart transplantation and immunosuppressive therapy
Lofdahl, Eveline
Radegran, Goran
[J]. TRANSPLANTATION REVIEWS, 2017, 31 (04) : 232 - 239
[6] HEART-TRANSPLANTATION - IMMUNOSUPPRESSIVE THERAPY AND COMPLICATIONS
GOENEN, M
COL, J
BAELE, P
PONLOT, R
SCHOEVARDTS, JC
NOEL, H
CHALANT, C
[J]. CARDIOLOGY, 1987, 74 (05) : 409 - 410
[7] DEVELOPMENTS IN IMMUNOSUPPRESSIVE THERAPY
DAAR, AS
[J]. TRANSPLANTATION PROCEEDINGS, 1995, 27 (05) : 2671 - 2675
[8] THE INDIVIDUAL TAILORING OF IMMUNOSUPPRESSIVE THERAPY AFTER HEART TRANSPLANTATION
Koloskova, N. N.
Poptsov, V. N.
Shevchenko, A. O.
[J]. VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV, 2018, 20 (01): : 127 - 137
[9] Analysis of the adverse effects of immunosuppressive therapy in heart transplantation
Almenar-Bonet, L
Rueda-Soriano, J
Osa-Saez, A
Arnau-Vives, MA
Martinez-Dolz, L
Gisbert, FD
Palencia-Pérez, M
[J]. TRANSPLANTATION PROCEEDINGS, 2002, 34 (01) : 134 - 136
[10] New developments in immunosuppressive drugs in the field of renal transplantation - Foreword
Philipp, T
Heemann, U
[J]. CLINICAL NEPHROLOGY, 1996, 45 (05) : 325 - 325

← 1 2 3 4 5 →