Label-free bioaffinity detection using terahertz technology

被引：131
|
作者：
Mickan, SP [1 ]
Menikh, A
Liu, HB
Mannella, CA
MacColl, R
Abbott, D
Munch, J
Zhang, XC
机构：
[1] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Ctr Terahertz Res, Troy, NY 12180 USA
[2] New York State Dept Hlth, Wadsworth Ctr Labs & Res, Albany, NY 12201 USA
[3] Univ Adelaide, Ctr Biomed Engn, Adelaide, SA 5005, Australia
[4] Univ Adelaide, Dept Elect & Elect Engn, Adelaide, SA 5005, Australia
[5] Univ Adelaide, Dept Phys & Math Phys, Adelaide, SA 5005, Australia
来源：
PHYSICS IN MEDICINE AND BIOLOGY | 2002年 / 47卷 / 21期
关键词：
D O I：
10.1088/0031-9155/47/21/317
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 mug cm(-2) of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation.
引用
收藏
页码：3789 / 3795
页数：7
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