Hydrodefluorination of Perfluoroarenes Meets Visible Light Photocatalysis

Partially fluorinated arenes are increasingly found in pharmaceuticals, agrochemicals and materials. While interest in these molecules is high, the number of available methods for their syntheses is severely limited. While installation of a single fluorine is achievable, installation of several fluorines represents a significant challenge. Approaching this synthetic problem from the opposite direction has been more fruitful. Specifically, by subjecting perfluorinated arenes to selective hydrodefluorination the desired molecules can be obtained. Herein, the advancement of this approach is discussed.