Calcitonin gene-related peptide and migraine with aura: A systematic review

被引:22
|
作者
Hansen, Jakob M.
Ashina, Messoud [1 ,2 ]
机构
[1] Univ Copenhagen, Fac Hlth & Med Sci, Glostrup Hosp, Danish Headache Ctr, DK-2600 Glostrup, Denmark
[2] Univ Copenhagen, Fac Hlth & Med Sci, Glostrup Hosp, Dept Neurol, DK-2600 Glostrup, Denmark
关键词
Calcitonin gene-related peptide; CGRP; migraine with aura; spreading depression; systematic review; CORTICAL SPREADING DEPRESSION; CGRP-RECEPTOR ANTAGONIST; RANDOMIZED CONTROLLED-TRIAL; RAT TRIGEMINAL GANGLION; IN-VIVO EVIDENCE; SUBSTANCE-P; EXTRACEREBRAL CIRCULATION; NEUROPEPTIDE CHANGES; PHARMACOLOGICAL CHARACTERIZATION; TRIGEMINOVASCULAR SYSTEM;
D O I
10.1177/0333102413520084
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Calcitonin gene-related peptide (CGRP) is a key molecule in migraine pathophysiology. Most studies have focused on CGRP in relation to migraine without aura (MO). About one-third of migraine patients have attacks with aura (MA), and this is a systematic review of the current literature on CGRP and MA. Methods: We performed a systematic literature search on MEDLINE for reports of CGRP and MA, covering basic science, animal and human studies as well as randomized clinical trials. Results: The literature search identified 594 citations, of which 38 contained relevant, original data. Plasma levels of CGRP in MA patients are comparable to MO, but CGRP levels varied among studies. A number of animal studies, including knock-ins of familial hemiplegic migraine (FHM) genes, have examined the relationship between CGRP and cortical spreading depression. In patients, CGRP does not trigger migraine in FHM, but is a robust trigger of migraine-like headache both in MA and MO patients. The treatment effect of CGRP antagonists are well proven in the treatment of migraine, but no studies have studied the effect specifically in MA patients. Conclusion: This systematic review indicates that the role of CGRP in MA is less studied than in MO. Further studies of the importance of CGRP for auras and migraine are needed.
引用
收藏
页码:695 / 707
页数:13
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