Synthetic Strategies for Peroxide Ring Construction in Artemisinin

被引：34
|
作者：
Vil', Vera A. [1 ,2 ,3 ]
Yaremenko, Ivan A. [1 ,2 ,3 ]
Ilovaisky, Alexey I. [1 ]
Terent'ev, Alexander O. [1 ,2 ,3 ]
机构：
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prospekt, Moscow 119991, Russia
[2] DI Mendeleev Univ Chem Technol Russia, Fac Chem & Pharmaceut Technol & Biomed Prod, 9 Miusskaya Sq, Moscow 125047, Russia
[3] All Russian Res Inst Phytopathol, B Vyazyomy 143050, Moscow Region, Russia
来源：
MOLECULES | 2017年 / 22卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
artemisinin; artemisinic acid; organic peroxide; peroxidation; cycles; STEREOSELECTIVE TOTAL-SYNTHESIS; DIHYDROARTEMISINIC ACID; ANTIMALARIAL-DRUG; SEMISYNTHETIC ARTEMISININ; SPONTANEOUS AUTOXIDATION; QINGHAOSU ARTEMISININ; MEDICINAL CHEMISTRY; MALARIA; CONVERSION; ANNUA;
D O I：
10.3390/molecules22010117
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present review summarizes publications on the artemisinin peroxide fragment synthesis from 1983 to 2016. The data are classified according to the structures of a precursor used in the key peroxidation step of artemisinin peroxide cycle synthesis. The first part of the review comprises the construction of artemisinin peroxide fragment in total syntheses, in which peroxide artemisinin ring resulted from reactions of unsaturated keto derivatives with singlet oxygen or ozone. In the second part, the methods of artemisinin synthesis based on transformations of dihydroartemisinic acid are highlighted.
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页数：20
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