Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration

被引：51
|
作者：
Feng, Chun [1 ,2 ]
Xue, Jianmin [1 ,2 ]
Yu, Xiaopeng [1 ,2 ]
Zhai, Dong [1 ,2 ]
Lin, Rongcai [3 ]
Zhang, Meng [1 ,2 ]
Xia, Lunguo [4 ]
Wang, Xiaoya [1 ,2 ]
Yao, Qingqiang [3 ]
Chang, Jiang [1 ,2 ]
Wu, Chengtie [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
[2] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
[3] Nanjing Med Univ, Nanjing Hosp 1, Digital Med Inst, Dept Orthopaed Surg, Nanjing 210006, Peoples R China
[4] Shanghai Jiao Tong Univ, Ctr Craniofacial Orthodont, Sch Med, Dept Oral & Craniomaxillofacial Sci,Peoples Hosp, Shanghai 200011, Peoples R China
来源：
ACTA BIOMATERIALIA | 2021年 / 119卷
基金：
中国国家自然科学基金;
关键词：
Co-inspired; Biomimetic material; Hydroxyapatite-based; Vascularized bone regeneration; REDUCED GRAPHENE OXIDE; ARTIFICIAL NACRE; OSTEOGENIC DIFFERENTIATION; IN-VIVO; DESIGN; NANOCOMPOSITES; TOUGH; BIOCOMPATIBILITY; COMPOSITES; STRENGTH;
D O I：
10.1016/j.actbio.2020.11.010
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Hydroxyapatite (HA) is the main inorganic component of human bone. Inspired by nacre and cortical bone, hydroxyapatite-based coil scaffolds were successfully prepared. The scaffolds presented "brick and mortar" multi-layered structure of nacre and multi-layered concentric circular structure of cortical bone. Because of bioactive components and hierarchical structure, the scaffolds possessed good compressive strength (approximate to 95 MPa), flexural strength (approximate to 161 MPa) and toughness (approximate to 1.1 MJ/m(3)). In addition, they showed improved angiogenesis and osteogenesis in rat and rabbit critical sized bone defect models. By mimicking co-biological systems, this work provided a feasible strategy to optimize the properties of traditional tissue engineering biological materials for vascularized bone regeneration. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：419 / 431
页数：13
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