Development and Execution of a Production-Scale Continuous [2+2] Photocycloaddition

被引：35

作者：

Beaver, Matthew G. ^{[3
]}

Zhang, En-xuan ^{[1
]}

Liu, Zhi-qing ^{[1
]}

Zheng, Song-yuan ^{[1
]}

Wang, Bin ^{[1
]}

Lu, Jiang-ping ^{[1
]}

Tao, Jian ^{[1
]}

Gonzalez, Miguel ^{[1
]}

Jones, Sian ^{[2
]}

Tedrow, Jason S. ^{[3
]}

机构：

[1] Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China

[2] Amgen Inc, Proc Dev, Thousand Oaks, CA 91320 USA

[3] Amgen Inc, Proc Dev, Cambridge, MA 02142 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2020年 / 24卷 / 10期

关键词：

photochemistry; photocycloaddition; continuous manufacturing; flow chemistry; FLOW PHOTOCHEMISTRY; MALEIC-ANHYDRIDE; LIGHT; REACTOR;

D O I：

10.1021/acs.oprd.0c00185

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This article details the approach to large-scale production of cyclobutane 2 by the continuous-flow [2 + 2] photocycloaddition of maleic anhydride and ethylene, including (1) focused reaction optimization and development of a robust isolation protocol, (2) the approach to equipment design and process safety, and (3) the results of commissioning tests and production runs delivering the target compound at throughputs exceeding 5 kg/day.

引用

页码：2139 / 2146

页数：8

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