Vulvovaginal-gingival Lichen Planus: Association with Lichen Planopilaris and Stratified Epithelium-specific Antinuclear Antibodies

被引：6
|
作者：
Olszewska, Malgorzata [1 ]
Banka-Wrona, Agnieszka [1 ]
Skrok, Anna [1 ]
Rakowska, Adriana [1 ]
Gorska, Renata [2 ]
Solomon, Lynn W. [3 ]
Rudnicka, Lidia [1 ,4 ]
机构：
[1] Med Univ Warsaw, Dept Dermatol, Koszykowa 82A, PL-02008 Warsaw, Poland
[2] Med Univ Warsaw, Dept Oral Med & Periodontol, PL-02008 Warsaw, Poland
[3] Nova SE Univ, Dept Oral Diagnost Sci, Ft Lauderdale, FL 33314 USA
[4] Polish Acad Sci, Mossakowski Med Res Ctr, Dept Neuropeptides, Warsaw, Poland
来源：
ACTA DERMATO-VENEREOLOGICA | 2016年 / 96卷 / 01期
关键词：
alopecia; chronic ulcerative stomatitis; dermoscopy; oral lichen planus; frontal fibrosing alopecia; vulvitis; trichoscopy; CHRONIC ULCERATIVE STOMATITIS; CLINICAL-FEATURES; INVOLVEMENT; TRICHOSCOPY; LESIONS; SCALP;
D O I：
10.2340/00015555-2141
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Vulvovaginal-gingival lichen planus (VVG-LP) consists of a triad of symptoms: vulval, vaginal and gingival lichen planus lesions. The aim of this study was to analyse the prevalence of lesions in various anatomical locations in patients with VVG-LP. The study included 126 consecutive patients with lichen planus. Sixteen (12.7%) patients fulfilled the criteria of VVG-LP. In 12/16 (75%) patients with VVG-LP scalp lesions were also observed. Stratified epithelium-specific antinuclear antibodies (SES-ANA) and anti-Delta Np.3 alpha antibodies were detected in 10/16 (75%) patients with VVG-LP and in 15/110 (13.6%) patients with other forms of lichen planus (p <0.05). In conclusion, VVG-LP is frequently associated with lichen planopilaris. The new entity may be termed "vulvovaginal-gingival-pilar lichen planus" and our study indicates that SES-ANA is a marker of this type of lichen planus with extensive, severe and refractory-to-therapy involvement of the mucous membranes, skin and scalp.
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页码：92 / 96
页数：5
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