Deep brain stimulation for Parkinson's disease - Consensus recommendations of the German Deep Brain Stimulation Association

被引：0

作者：

Hilker, R. ^{[2
]}

Benecke, R. ^{[3
]}

Deuschl, G. ^{[4
]}

Fogel, W. ^{[5
]}

Kupsch, A. ^{[6
]}

Schrader, C. ^{[7
]}

Sixel-Doering, F. ^{[8
]}

Timmermann, L. ^{[9
]}

Volkmann, J. ^{[4
]}

Lange, M. ^{[1
]}

机构：

[1] Univ Klinikum, Klin & Poliklin Neurochirurg, D-93053 Regensburg, Germany

[2] Goethe Univ Frankfurt, Zentrum Neurol & Neurochirurg, Neurol Klin, Frankfurt, Germany

[3] Neurol Univ Klin, Rostock, Germany

[4] Univ Kiel, Neurol Klin, D-2300 Kiel, Germany

[5] Deutsch Klin Diagnost, FB Neurol, D-6200 Wiesbaden, Germany

[6] Charite, Zentrum Neurol, D-13353 Berlin, Germany

[7] Hannover Med Sch, Neurol Klin Klin Neurophysiol, D-30623 Hannover, Germany

[8] Paracelsus Elena Klin, Kassel, Germany

[9] Univ Klinikum, Klin & Poliklin Neurol, Cologne, Germany

来源：

NERVENARZT | 2009年 / 80卷 / 06期

关键词：

Parkinson's disease; Deep brain stimulation; Consensus recommendations; SUBTHALAMIC NUCLEUS STIMULATION; UNILATERAL PALLIDAL STIMULATION; CHRONIC BILATERAL STIMULATION; HIGH-FREQUENCY STIMULATION; TERM FOLLOW-UP; THALAMIC-STIMULATION; GLOBUS-PALLIDUS; ELECTRICAL-STIMULATION; CONSECUTIVE SERIES; COGNITIVE FUNCTION;

D O I：

10.1007/s00115-009-2695-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Deep brain stimulation (DBS) has been shown to be effective for levodopa-responsive symptoms and tremor in Parkinson's disease (PD). The subthalamic nucleus (STN) is the preferred target for most patients suffering from late stage motor complications of the disorder. STN DBS is superior to best medical treatment concerning the control of motor fluctuations and the increase of on-time without dyskinesias. In contrast to DBS of the internal pallidum (GPi), STN stimulation also permits a reduction of the dopaminergic medication. Long-term data demonstrated sustained effectiveness of STN DBS despite progressive disease. DBS of the thalamic ventral intermediate nucleus (VIM) is an alternative target in older PD patients with severe PD tremor refractory to medication. In order to minimize potential risks and side effects, the use of DBS needs careful adherence to inclusion and exclusion criteria for eligible PD patients. This paper summarizes the current consensus recommendations of the German Deep Brain Stimulation Association for DBS in PD.

引用

页码：646 / +

页数：8

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