On-line Monitoring: Animal Cell Cultivation in iCELLisTM Fixed-Bed Reactor Using Dielectric Measurements

被引：2

作者：

Drugmand, Jean-Christophe ^{[1
]}

Esteban, Geoffrey ^{[2
]}

Alaoui, Naima ^{[1
]}

Jafar, Nadia ^{[1
]}

Havelange, Nicolas ^{[1
]}

Berteau, Olivier ^{[2
]}

Castillo, Jose ^{[1
]}

机构：

[1] ATMI LifeSci Artelis, Brussels, Belgium

[2] Fogale Nanotech, Nimes, France

来源：

PROCEEDINGS OF THE 21ST ANNUAL MEETING OF THE EUROPEAN SOCIETY FOR ANIMAL CELL TECHNOLOGY (ESACT), 2009 | 2012年 / 5卷

关键词：

D O I：

10.1007/978-94-007-0884-6_65

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Artelis/ATMI LifeSciences has developed a novel scalable fixed-bed bioreactor - iCELLis(TM) based on a proprietary agitation system, a waterfall oxygenation of medium and a packed-bed made up of macroporous carriers. Here we present the use of a permittivity-based biomass probe developed by Fogale to monitors and controls a Vero cell culture producing viruses in such iCELLis fixed-bed. We demonstrate that using a biomass sensor in a fixed-bed bioreactor can follow cell growth and cell lysis (due to viral infection).

引用

页码：395 / 399

页数：5

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