ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer

被引：133
|
作者：
D'Angelo, Stefania [1 ]
Motti, Maria Letizia [1 ]
Meccariello, Rosaria [1 ]
机构：
[1] Univ Napoli Parthenope, Dipartimento Sci Motorie & Benessere, Via Medina 40, I-80133 Naples, Italy
来源：
NUTRIENTS | 2020年 / 12卷 / 09期
关键词：
obesity; omega-3PUFAs; omega-6PUFAs; endocannabinoids; CRC; fatty acids; ADIPOSE-TISSUE INFLAMMATION; M2 MACROPHAGE POLARIZATION; LONG-CHAIN OMEGA-3; STEM-LIKE CELLS; COLORECTAL-CANCER; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; N-3; PUFAS; CARDIOVASCULAR-DISEASE; CANNABINOID RECEPTOR;
D O I：
10.3390/nu12092751
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Recently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (omega-3PUFAs), including alpha-linolenic acid, docosapentaenoic acid, and eicosapentaenoic acid, are mostly attractive. They are available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. The anti-inflammatory and hypotriglyceridemic effects of these fatty acids are well known, whereas pro-inflammatory properties have been recognized in their dietary counterparts, the omega-6PUFAs. Both omega-3 and omega-6PUFAs contribute to the production of lipid mediators such as endocannabinoids that are notably involved in control of food intake, energy sensing, and food-related disorders. In this review, we present omega-3 and omega-6PUFAs and their derivatives, endocannabinoids; discuss the anti-obesity effects of omega-3PUFAs; their roles in inflammation and colorectal cancer development; and how their action can be co-preventative and co-therapeutic.
引用
收藏
页码：1 / 22
页数：22
相关论文
共 50 条
  • [1] ω-6 and ω-3 Polyunsaturated Fatty Acids: Inflammation, Obesity and Foods of Animal Resources
    Jeong, Hwa Yeong
    Moon, Yang Soo
    Cho, Kwang Keun
    [J]. FOOD SCIENCE OF ANIMAL RESOURCES, 2024, 44 (05) : 988 - 1010
  • [2] Importance of the Role of ω-3 and ω-6 Polyunsaturated Fatty Acids in the Progression of Brain Cancer
    Montecillo-Aguado, Mayra
    Tirado-Rodriguez, Belen
    Tong, Zhen
    Vega, Owen M.
    Morales-Martinez, Mario
    Abkenari, Shaheen
    Pedraza-Chaverri, Jose
    Huerta-Yepez, Sara
    [J]. BRAIN SCIENCES, 2020, 10 (06) : 1 - 18
  • [3] Dietary intakes of ω-6 and ω-3 polyunsaturated fatty acids and the risk of breast cancer
    Thiebaut, Anne C. M.
    Chajes, Veronique
    Gerber, Mariette
    Boutron-Ruault, Marie-Christine
    Joulin, Virginie
    Lenoir, Gilbert
    Berrino, Franco
    Riboli, Elio
    Benichou, Jacques
    Clavel-Chapelon, Francoise
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (04) : 924 - 931
  • [4] Omega-6 polyunsaturated fatty acids and the early origins of obesity
    Muhlhausler, Beverly S.
    Ailhaud, Gerard P.
    [J]. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2013, 20 (01) : 56 - 61
  • [5] Implications of dietary ω-3 and ω-6 polyunsaturated fatty acids in breast cancer (Review)
    Zanoaga, Oana
    Jurj, Ancuta
    Raduly, Lajos
    Cojocneanu-Petric, Roxana
    Fuentes-Mattei, Enrique
    Wu, Oscar
    Braicu, Cornelia
    Gherman, Claudia Diana
    Berindan-Neagoe, Ioana
    [J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 15 (02) : 1167 - 1176
  • [6] Omega-3 Polyunsaturated Fatty Acids and Cancer
    Jing, Kaipeng
    Wu, Tong
    Lim, Kyu
    [J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2013, 13 (08) : 1162 - 1177
  • [7] Polyunsaturated fatty acids, obesity and the metabolic syndrome
    Vessby, B
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 : S37 - S37
  • [8] n-6 polyunsaturated fatty acids and breast cancer
    Tokudome, S
    Kuriki, K
    Suzuki, S
    Nahomi, I
    Goto, C
    Tokudome, Y
    Takeda, E
    Ichikawa, Y
    Okuyama, H
    [J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2003, 47 (02): : 210 - 210
  • [9] ω-3 and ω-6 polyunsaturated fatty acids block HERG channels
    Guizy, M
    Arias, C
    David, M
    González, T
    Valenzuela, C
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2005, 289 (05): : C1251 - C1260
  • [10] n-3 polyunsaturated fatty acids and breast cancer
    Lhuillery, C
    Cognault, S
    Germain, E
    Chajes, V
    Bougnoux, P
    [J]. BREAST CANCER - ADVANCES IN BIOLOGY AND THERAPEUTICS, 1996, : 59 - 65
12345