Reinforcement of amniotic membrane with fibrin coated poly-[Lactide-co-Glycolide-co-Caprolactone] terpolymer containing silver nanoparticles for potential wound healing applications

被引：12
|
作者：
Ramakrishnan, Rashmi [1 ]
Krishnan, Lissy K. [1 ]
Nair, Renjith P. [1 ]
Krishnan, V. Kalliyana [2 ]
机构：
[1] Sree Chitra Tirunal Inst Med Sci & Technol, Dept Appl Biol, Biomed Technol Wing, Thiruvananthapuram, Kerala, India
[2] Sree Chitra Tirunal Inst Med Sci & Technol, Dept Biomat Sci & Technol, Biomed Technol Wing, Thiruvananthapuram 695012, Kerala, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2020年 / 69卷 / 12期
关键词：
Amniotic membrane; Fibrin; PLGC Terpolymer; Combination scaffold; Wound healing; EPSILON-CAPROLACTONE; TISSUE; LACTIDE; GRAFTS; REPAIR; SKIN;
D O I：
10.1080/00914037.2019.1626388
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Human amniotic membrane (AM) is reported to possess remarkable therapeutic potential for wound healing due to its inherent bioactive and biocompatible properties. However, poor handling characteristics have limited its clinical use on wounds to a great extent. Reinforcement of AM with a biodegradable polymer is therefore expected to provide adequate mechanical and handling nature. Poly-[Lactide-co-Glycolide-co-Caprolactone] terpolymer incorporated with silver nanoparticles and coated with fibrin is used in this study to reinforce the membrane which delivers bioactive molecules to the wound site without wound contraction. This combination scaffold exhibited desirable properties with excellent biocompatibility for potential use in wound healing applications. [GRAPHICS] .
引用
收藏
页码：810 / 819
页数：10
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