Bridging long gap peripheral nerve injury using skeletal muscle-derived multipotent stem cells

被引：16
|
作者：
Tamaki, Tetsuro [1 ]
机构：
[1] Tokai Univ, Sch Med, Dept Regenerat Med, Muscle Physiol & Cell Biol Unit,Div Basic Clin Sc, Isehara, Kanagawa 2591143, Japan
来源：
NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 14期
关键词：
peripheral nerve support cells; Schwann cells; perineurium; endoneurium; cytokine; paracrine effect; blood vessel formation; GUIDANCE CHANNELS; GROWTH-FACTOR; IN-VITRO; REGENERATION; SOX10; RECONSTRUCTION; RECONSTITUTION; CONDUIT; FIBERS; GRAFT;
D O I：
10.4103/1673-5374.137582
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Long gap peripheral nerve injuries usually reulting in life-changing problems for patients. Skeletal muscle derived-multipotent stem cells (Sk-MSCs) can differentiate into Schwann and perineurial/endoneurial cells, vascular relating pericytes, and endothelial and smooth muscle cells in the damaged peripheral nerve niche. Application of the Sk-MSCs in the bridging conduit for repairing long nerve gap injury resulted favorable axonal regeneration, which showing superior effects than gold standard therapy--healthy nerve autograft. This means that it does not need to sacrifice of healthy nerves or loss of related functions for repairing peripheral nerve injury.
引用
收藏
页码：1333 / 1336
页数：4
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