Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase

被引：141
|
作者：
Odobasic, Dragana [1 ]
Kitching, A. Richard [1 ,2 ]
Holdsworth, Stephen R. [1 ,2 ]
机构：
[1] Monash Univ, Dept Med, Monash Med Ctr, Ctr Inflammatory Dis, Clayton, Vic 3168, Australia
[2] Monash Hlth, Dept Nephrol, Clayton, Vic 3168, Australia
来源：
JOURNAL OF IMMUNOLOGY RESEARCH | 2016年 / 2016卷
关键词：
HIGH-DENSITY-LIPOPROTEIN; EXTRACELLULAR TRAPS; ENDOGENOUS MYELOPEROXIDASE; MACROPHAGE ACTIVATION; NETTING NEUTROPHILS; INDUCED ARTHRITIS; OXIDATIVE STRESS; DENDRITIC CELLS; MICE DEFICIENT; RENAL-DISEASE;
D O I：
10.1155/2016/2349817
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.
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页数：11
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