Trends in Prevalence and Control of Diabetes in the United States, 1988-1994 and 1999-2010

Background: Trends in the prevalence and control of diabetes defined by hemoglobin A(1c) (HbA(1c)) levels are important for health care policy and planning. Objective: To update trends in the prevalence of diabetes, prediabetes, and glycemic control. Design: Cross-sectional. Setting: NHANES (National Health and Nutrition Examination Survey) in 1988-1994 and 1999-2010. Participants: Adults aged 20 years or older. Measurements: We used calibrated HbA(1c) levels to define undiagnosed diabetes (>= 6.5%); prediabetes (5.7% to 6.4%); and, among persons with diagnosed diabetes, glycemic control (<7.0% or <8.0%). Trends in HbA(1c) categories were compared with fasting glucose levels (>= 7.0 mmol/L [>= 126 mg/dL] and 5.6 to 6.9 mmol/L [100 to 125 mg/dL]). Results: In 2010, approximately 21 million U. S. adults aged 20 years or older had total confirmed diabetes (self-reported diabetes or diagnostic levels for both fasting glucose and calibrated HbA(1c)). During 2 decades, the prevalence of total confirmed diabetes in-creased, but the prevalence of undiagnosed diabetes remained fairly stable, reducing the proportion of total diabetes cases that are undiagnosed to 11% in 2005-2010. The prevalence of prediabetes was lower when defined by calibrated HbA(1c) levels than when defined by fasting glucose levels but has increased from 5.8% in 1988-1994 to 12.4% in 2005-2010 when defined by HbA(1c) levels. Glycemic control improved overall, but total diabetes prevalence was greater and diabetes was less controlled among non-Hispanic blacks and Mexican Americans compared with non-Hispanic whites. Limitation: Cross-sectional design. Conclusion: Over the past 2 decades, the prevalence of total diabetes has increased substantially. However, the proportion of undiagnosed diabetes cases decreased, suggesting improvements in screening and diagnosis. Among the growing number of persons with diagnosed diabetes, glycemic control improved but remains a challenge, particularly among non-Hispanic blacks and Mexican Americans.