GSG1L regulates the strength of AMPA receptor-mediated synaptic transmission but not AMPA receptor kinetics in hippocampal dentate granule neurons

被引：19
|
作者：
Mao, Xia [1 ]
Gu, Xinglong [1 ]
Lu, Wei [1 ]
机构：
[1] NINDS, Synapse & Neural Circuit Res Unit, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF NEUROPHYSIOLOGY | 2017年 / 117卷 / 01期
关键词：
AMPA receptor; GSG1L; deactivation; desensitization; synapse; hippocampus; outside-out patch; TRANSMEMBRANE AUXILIARY SUBUNITS; CALCIUM-PERMEABLE AMPARS; GLUTAMATE RECEPTORS; CORNICHON PROTEINS; TARPS; STARGAZIN; TRAFFICKING; PLASTICITY; EXPRESSION; DESENSITIZATION;
D O I：
10.1152/jn.00307.2016
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
GSG1L is an AMPA receptor (AMPAR) auxiliary subunit that regulates AMPAR trafficking and function in hippocampal CA1 pyramidal neurons. However, its physiological roles in other types of neurons remain to be characterized. Here, we investigated the role of GSG1L in hippocampal dentate granule cells and found that GSG1L is important for the regulation of synaptic strength but is not critical for the modulation of AMPAR deactivation and desensitization kinetics. These data demonstrate a neuronal type-specific role of GSG1L and suggest that physiological function of AMPAR auxiliary subunits may vary in different types of neurons. NEW & NOTEWORTHY GSG1L is a newly identified AMPA receptor (AMPAR) auxiliary subunit and plays a unique role in the regulation of AMPAR trafficking and function in hippocampal CA1 pyramidal neurons. However, its role in the regulation of AMPARs in hippocampal dentate granule cells remains to be characterized. The current work reveals that GSG1L regulates strength of AMPAR-mediated synaptic transmission but not the receptor kinetic properties in hippocampal dentate granule neurons.
引用
收藏
页码：28 / 35
页数：8
相关论文
共 50 条
  • [1] GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons
    Gu, Xinglong
    Mao, Xia
    Lussier, Marc P.
    Hutchison, Mary Anne
    Zhou, Liang
    Hamra, F. Kent
    Roche, Katherine W.
    Lu, Wei
    [J]. NATURE COMMUNICATIONS, 2016, 7
  • [2] GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons
    Xinglong Gu
    Xia Mao
    Marc P. Lussier
    Mary Anne Hutchison
    Liang Zhou
    F. Kent Hamra
    Katherine W. Roche
    Wei Lu
    [J]. Nature Communications, 7
  • [3] Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L
    Shanks, Natalie F.
    Savas, Jeffrey N.
    Maruo, Tomohiko
    Cais, Ondrej
    Hirao, Atsushi
    Oe, Souichi
    Ghosh, Anirvan
    Noda, Yasuko
    Greger, Ingo H.
    Yates, John R., III
    Nakagawa, Terunaga
    [J]. CELL REPORTS, 2012, 1 (06): : 590 - 598
  • [4] AMPA Receptor Activation Causes Silencing of AMPA Receptor-Mediated Synaptic Transmission in the Developing Hippocampus
    Wasling, Pontus
    Strandberg, Joakim
    Hanse, Eric
    [J]. PLOS ONE, 2012, 7 (04):
  • [5] Suppression by zinc of AMPA receptor-mediated synaptic transmission in the retina
    Zhang, DQ
    Ribelayga, C
    Mangel, SC
    McMahon, DG
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (03) : 1245 - 1251
  • [6] AMPA and NMDA receptor-mediated currents in developing dentate gyrus granule cells
    Ye, GL
    Yi, S
    Gamkrelidze, G
    Pasternak, JF
    Trommer, BL
    [J]. DEVELOPMENTAL BRAIN RESEARCH, 2005, 155 (01): : 26 - 32
  • [7] Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission
    Lussier, Marc P.
    Herring, Bruce E.
    Nasu-Nishimura, Yukiko
    Neutzner, Albert
    Karbowski, Mariusz
    Youle, Richard J.
    Nicoll, Roger A.
    Roche, Katherine W.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (47) : 19426 - 19431
  • [8] AMPA receptor complexes with type II TARP Gamma-5 and GSG1L
    Klykov, Oleg
    Gangwar, Shanti Pal
    Yelshanskaya, Maria V.
    Yen, Laura
    Sobolevsky, Alexander I.
    [J]. BIOPHYSICAL JOURNAL, 2022, 121 (03) : 382A - 382A
  • [9] Structure and desensitization of AMPA receptor complexes with type II TARP γ5 and GSG1L
    Klykov, Oleg
    Gangwar, Shanti Pal
    Yelshanskaya, Maria V.
    Yen, Laura
    Sobolevsky, Alexander I.
    [J]. MOLECULAR CELL, 2021, 81 (23) : 4771 - +
  • [10] Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses.
    Lauri, SE
    Delany, C
    Clarke, VRJ
    Bortolotto, ZA
    Ornstein, PL
    Isaac, JTR
    Collingridge, GL
    [J]. NEUROPHARMACOLOGY, 2001, 41 (08) : 907 - 915
12345