Norisoprenoids and hepatoprotective flavone glycosides from the aerial parts of Beta vulgaris var. cicla

被引：39
|
作者：
Kim, I
Chin, YW
Lim, SW
Kim, YC
Kim, J [1 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 06期
关键词：
Beta vulgaris var. cicla; hepatoprotective activity; flavonoid; (+)-dehydrovomifoliol; 3-hydroxy-5; alpha; 6; alpha-epoxy-beta-ionone; vitexin; 7-O-beta-D-glucopyranoside; vitexin 2 ''-O-beta-D-glucopyranoside;
D O I：
10.1007/BF02980156
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
(+)-Dehydrovomifoliol (1), 3-hydroxy-5alpha,6alpha-epoxy-beta-ionone (2), vitexin 7-O-beta-D-glucopyranoside (3), and vitexin 2"-O-beta-D-glucopyranoside (4) were isolated as new constituents from the aerial parts of Beta vulgaris var. cicla. Compounds 3 and 4 demonstrated hepatoprotective activity with values of 65.8 and 56.1%, respectively, in primary cultured rat hepatocytes with CCl4-induced cell toxicity, compared to controls. This was comparable to that of silibinin (69.8 %) which was used as a positive control.
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收藏
页码：600 / 603
页数：4
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