Offspring psychopathology following preconception, prenatal and postnatal maternal bereavement stress

被引:136
|
作者
Class, Q. A. [1 ]
Abel, K. M. [2 ]
Khashan, A. S. [3 ]
Rickert, M. E. [1 ]
Dalman, C. [4 ]
Larsson, H. [5 ]
Hultman, C. M. [5 ]
Langstrom, N. [5 ]
Lichtenstein, P. [5 ]
D'Onofrio, B. M. [1 ]
机构
[1] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
[2] Univ Manchester, Ctr Womens Mental Hlth, Manchester Acad Hlth Sci, Manchester M13 9PL, Lancs, England
[3] Natl Univ Ireland Univ Coll Cork, Dept Obstet & Gynaecol, Anu Res Ctr, Cork, Ireland
[4] Karolinska Inst, Dept Publ Hlth Sci, Div Publ Hlth Epidemiol, Stockholm, Sweden
[5] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
基金
瑞典研究理事会;
关键词
Attention deficit hyperactivity disorder; autism; postnatal; preconception; prenatal; psychiatric; psychopathology; schizophrenia; stress; suicide; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SEVERE LIFE EVENTS; RISK-FACTORS; PRETERM BIRTH; PSYCHIATRIC-DISORDERS; DEPRESSED MOTHERS; SUICIDAL-BEHAVIOR; HEALTH OUTCOMES; FAMILIAL RISK; HPA-AXIS;
D O I
10.1017/S0033291713000780
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background. Preconception, prenatal and postnatal maternal stress is associated with increased offspring psychopathology, but findings are inconsistent and need replication. We estimated associations between maternal bereavement stress and offspring autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), bipolar disorder, schizophrenia, suicide attempt and completed suicide. Method. Using Swedish registers, we conducted the largest population-based study to date examining associations between stress exposure in 738144 offspring born 1992-2000 for childhood outcomes and 2155221 offspring born 1973-1997 for adult outcomes with follow-up to 2009. Maternal stress was defined as death of a first-degree relative during (a) the 6 months before conception, (b) pregnancy or (c) the first two postnatal years. Cox proportional survival analyses were used to obtain hazard ratios (HRs) in unadjusted and adjusted analyses. Results. Marginal increased risk of bipolar disorder and schizophrenia following preconception bereavement stress was not significant. Third-trimester prenatal stress increased the risk of ASD [ adjusted HR (aHR) 1.58, 95% confidence interval (CI) 1.15-2.17] and ADHD (aHR 1.31, 95% CI 1.04-1.66). First postnatal year stress increased the risk of offspring suicide attempt (aHR 1.13, 95% CI 1.02-1.25) and completed suicide (aHR 1.51, 95% CI 1.08-2.11). Bereavement stress during the second postnatal year increased the risk of ASD (aHR 1.30, 95% CI 1.09-1.55). Conclusions. Further research is needed regarding associations between preconception stress and psychopathological outcomes. Prenatal bereavement stress increases the risk of offspring ASD and ADHD. Postnatal bereavement stress moderately increases the risk of offspring suicide attempt, completed suicide and ASD. Smaller previous studies may have overestimated associations between early stress and psychopathological outcomes.
引用
收藏
页码:71 / 84
页数:14
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