Attention deficit hyperactivity disorder;
autism;
postnatal;
preconception;
prenatal;
psychiatric;
psychopathology;
schizophrenia;
stress;
suicide;
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
SEVERE LIFE EVENTS;
RISK-FACTORS;
PRETERM BIRTH;
PSYCHIATRIC-DISORDERS;
DEPRESSED MOTHERS;
SUICIDAL-BEHAVIOR;
HEALTH OUTCOMES;
FAMILIAL RISK;
HPA-AXIS;
D O I:
10.1017/S0033291713000780
中图分类号:
B849 [应用心理学];
学科分类号:
040203 ;
摘要:
Background. Preconception, prenatal and postnatal maternal stress is associated with increased offspring psychopathology, but findings are inconsistent and need replication. We estimated associations between maternal bereavement stress and offspring autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), bipolar disorder, schizophrenia, suicide attempt and completed suicide. Method. Using Swedish registers, we conducted the largest population-based study to date examining associations between stress exposure in 738144 offspring born 1992-2000 for childhood outcomes and 2155221 offspring born 1973-1997 for adult outcomes with follow-up to 2009. Maternal stress was defined as death of a first-degree relative during (a) the 6 months before conception, (b) pregnancy or (c) the first two postnatal years. Cox proportional survival analyses were used to obtain hazard ratios (HRs) in unadjusted and adjusted analyses. Results. Marginal increased risk of bipolar disorder and schizophrenia following preconception bereavement stress was not significant. Third-trimester prenatal stress increased the risk of ASD [ adjusted HR (aHR) 1.58, 95% confidence interval (CI) 1.15-2.17] and ADHD (aHR 1.31, 95% CI 1.04-1.66). First postnatal year stress increased the risk of offspring suicide attempt (aHR 1.13, 95% CI 1.02-1.25) and completed suicide (aHR 1.51, 95% CI 1.08-2.11). Bereavement stress during the second postnatal year increased the risk of ASD (aHR 1.30, 95% CI 1.09-1.55). Conclusions. Further research is needed regarding associations between preconception stress and psychopathological outcomes. Prenatal bereavement stress increases the risk of offspring ASD and ADHD. Postnatal bereavement stress moderately increases the risk of offspring suicide attempt, completed suicide and ASD. Smaller previous studies may have overestimated associations between early stress and psychopathological outcomes.
机构:
Univ Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USA
Rinne, Gabrielle R.
Barclay, Margot E.
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USA
Barclay, Margot E.
Somers, Jennifer A.
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USA
Somers, Jennifer A.
Mahrer, Nicole E.
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h-index: 0
机构:
Univ La Verne, Dept Psychol, La Verne, CA USAUniv Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USA
Mahrer, Nicole E.
Shalowitz, Madeleine U.
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h-index: 0
机构:
Rush Univ, Med Ctr, Dept Pediat, Chicago, IL USAUniv Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USA
Shalowitz, Madeleine U.
Ramey, Sharon Landesman
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h-index: 0
机构:
Virginia Polytech Inst & State Univ, Fralin Biomed Res Inst, Dept Psychol, Blacksburg, VA USAUniv Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USA
Ramey, Sharon Landesman
Schetter, Christine Dunkel
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USA
Schetter, Christine Dunkel
Lee, Steve S.
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, 502 Portola Plaza,1285 Psychol Bldg, Los Angeles, CA 90095 USA
机构:
Univ Western Australia, Sch Populat & Global Hlth, Perth, AustraliaUniv Western Australia, Telethon Kids Inst, Perth, Australia
Lin, Ashleigh
Jacoby, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Australia, Telethon Kids Inst, Perth, AustraliaUniv Western Australia, Telethon Kids Inst, Perth, Australia
Jacoby, Peter
Eikelboom, Robert
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h-index: 0
机构:
Univ Western Australia, Ear Sci Ctr, Med Sch, Perth, Australia
Ear Sci Inst Australia, Perth, Australia
Univ Pretoria, Dept Speech Language Pathol & Audiol, Pretoria, South Africa
Curtin Univ, Fac Hlth Sci, Perth, WA, AustraliaUniv Western Australia, Telethon Kids Inst, Perth, Australia
Eikelboom, Robert
Vijayasekaran, Shyan
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机构:
Perth ENT Ctr, Perth, Australia
Perth Childrens Hosp, Otolaryngol Head & Neck Surg, Perth, Australia
Univ Western Australia, Med Sch, Perth, AustraliaUniv Western Australia, Telethon Kids Inst, Perth, Australia
Vijayasekaran, Shyan
Brennan-Jones, Christopher G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Australia, Telethon Kids Inst, Perth, AustraliaUniv Western Australia, Telethon Kids Inst, Perth, Australia