IFNG and IFNGR1 gene polymorphisms in children with nonresponse to the hepatitis B vaccine

被引：3
|
作者：
Ciftdogan, Dilek Yilmaz [1 ]
Onay, Huseyin [2 ]
Tosun, Selam [3 ]
Ozdemir, Taha Resid [2 ]
Ozkinay, Ferda [2 ]
Vardar, Fadil [1 ]
机构：
[1] Ege Univ, Fac Med, Dept Pediat Infect Dis, Izmir, Turkey
[2] Ege Univ, Dept Med Genet, Izmir, Turkey
[3] Manisa State Hosp, Manisa, Turkey
来源：
FUTURE VIROLOGY | 2014年 / 9卷 / 02期
关键词：
child; gene polymorphism; hepatitisB; IFN-; interferon gamma; vaccine; TH2 CYTOKINE PRODUCTION; INTERFERON-GAMMA GENE; RECEPTOR; DEFICIENCY; VIRUS INFECTION; ANTIGEN; IMMUNOGENICITY; IMMUNIZATION; RISK; SUSCEPTIBILITY; REVACCINATION;
D O I：
10.2217/fvl.13.124
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: We investigated the +874 T/A polymorphism in the first intron of the IFNG gene and intronic (CA)(n) polymorphic microsatellite marker of the IFNGR1 gene in child nonresponders to hepatitisB vaccination. Materials & methods: A total of 100 children who had anti-HBs antibody levels <10 mIU/ml after vaccination against hepatitisB were included as a nonresponder group and 100 children who had anti-HBs antibody levels >10mIU/ml after vaccination against hepatitisB were included as a responder group. Results: The frequency of the TT genotype of the IFNG (+874 T/A) gene polymorphism was higher in nonresponders (p = 0.003). The frequencies of alleles 170 and 182 for (CA)(n) alleles for the intronic (CA)(n) microsatellite of IFNGR1 were significantly higher in nonresponders (for each, p<0.05). Conclusion: The TT genotype of the IFNG (+874 T/A) gene, and alleles 170 and 182 for (CA)(n) alleles for the intronic (CA)(n) microsatellite of the IFNGR1 gene, may be associated with nonresponse to hepatitisB vaccination.
引用
收藏
页码：123 / 130
页数：8
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