Protein phosphatase 2A regulatory subunits and cancer

被引：408
|
作者：
Eichhorn, Pieter J. A.
Creyghton, Menno P.
Bernards, Rene [1 ]
机构：
[1] Netherlands Canc Inst, Ctr Canc Genom, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2009年 / 1795卷 / 01期
关键词：
Protein phosphatase 2A; Signal transduction; Cancer; A-BETA-SUBUNIT; ADENOVIRUS E4ORF4 PROTEIN; MIDDLE-T-ANTIGEN; KAPPA-B-KINASE; TERMINAL LEUCINE RESIDUE; TUMOR-SUPPRESSOR PP2A; CELL-CYCLE ARREST; CATALYTIC SUBUNIT; OKADAIC ACID; SERINE/THREONINE PHOSPHATASE;
D O I：
10.1016/j.bbcan.2008.05.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an integral role in the regulation of a number of major signaling pathways whose deregulation can contribute to cancer. The specificity and activity of PP2A are highly regulated through the interaction of a family of regulatory B subunits with the substrates. Accumulating evidence indicates that PP2A acts as a tumor suppressor. In this review we summarize the known effects of specific PP2A holoenzymes and their roles in cancer relevant pathways. In particular we highlight PP2A function in the regulation of MAPK and Writ signaling. (C) 2008 Elsevier B.V. All rights reserved.
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页码：1 / 15
页数：15
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