Effect of gallic acid on renal biochemical alterations in male Wistar rats induced by ferric nitriloacetic acid

被引:21
|
作者
Prasad, Lakshmi [1 ]
Khan, Tajdar Husain [1 ]
Jahangir, Tamanna [1 ]
Sultana, Sarwat [1 ]
机构
[1] Hamdard Univ, Dept Med Elementol & Toxicol, Fac Sci, Sect Chemoprevent & Nutr Toxicol, New Delhi 110062, India
关键词
antioxidant enzymes; cell proliferative response; chemoprevention; ferric nitrilotriacetate; gallic acid;
D O I
10.1191/0960327106het652oa
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The present study is an effort to identify a potent chemopreventive agent against various diseases (including cancer) in which oxidative stress and cell proliferation plays an important causative role. This study was designed to investigate the effect of gallic acid against ferric nitrilotriacetic acid (Fe-NTA)-induced carcinogen/drug metabolizing phase I and phase II enzymes, anti-oxidative parameters, kidney markers, tumour promotion markers and lipid peroxidation (LPO) in kidney of male Wistar rats. Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) caused significant depletion in the detoxification and antioxidant enzyme armoury with concomitant elevation in renal LPO, serum creatinine, blood urea nitrogen, hydrogen peroxide generation, ornithine decarboxylase activity and [H-3]thymidine incorporation into renal DNA. However, pretreatment of animals with gallic acid (10 and 20 mg/kg body weight) resulted in a significant decrease in the levels of the parameters measured (P < 0.001). Renal glutathione content (P < 0.001), glutathione metabolizing enzyme (P < 0.001) and antioxidant enzyme levels were also recovered to a significant level (P < 0.001). The enhanced reduced glutathione level and enzyme activities involved in xenobiotic metabolism and maintaining antioxidant status of cells are suggestive of a chemopreventive efficacy of gallic acid against Fe-NTA-mediated oxidative stress, toxicity and cell proliferative response in Wistar rats.
引用
收藏
页码:523 / 529
页数:7
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