The human papillomavirus type 16 E6 oncogene induces premature mitotic chromosome segregation

被引：15
|
作者：
Plug-Demaggio, AW
McDougall, JK
机构：
[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
[2] Fred Hutchinson Canc Res Ctr, Canc Biol Program, Seattle, WA 98109 USA
来源：
ONCOGENE | 2002年 / 21卷 / 49期
关键词：
genetic instability; chromosome segregation; HPV; 16; E6;
D O I：
10.1038/sj.onc.1205903
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Expression of the human papillomavirus type 16 E6 and E7 oncogenes initiates and maintains abnormal cell replication, by interacting with the p53 and retinoblastoma (Rb) gene products. Subsequent changes in host cell gene expression, as a consequence of genetic instability, can result in progression to invasive carcinoma. In addition to previously described effects of these viral oncogenes on centrosome synthesis, primarily associated with the expression of E7, the results described herein demonstrate that the E6 oncogene can induce premature chromosome segregation in human cells.
引用
收藏
页码：7507 / 7513
页数：7
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