A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

被引：91
|
作者：
Cai, Hui-Juan [1 ]
Shen, Ting-Ting [1 ]
Zhang, Jian [2 ]
Shan, Chang-Fu [1 ]
Jia, Jian-Guo [1 ]
Li, Xiang [1 ]
Liu, Wei-Sheng [1 ]
Tang, Yu [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China
[2] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 13期
基金：
中国国家自然科学基金;
关键词：
UP-CONVERSION NANOPARTICLES; HIGHLY EFFICIENT; METHYLENE-BLUE; OXYGEN; MOLECULES; LIGHT;
D O I：
10.1039/c7tb00314e
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Core-shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@ catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.
引用
收藏
页码：2390 / 2394
页数：5
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