Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components

被引：45
|
作者：
Delfino, D [1 ]
Cianci, L [1 ]
Lupis, E [1 ]
Celeste, A [1 ]
Petrelli, ML [1 ]
Curro, F [1 ]
Cusumano, V [1 ]
Teti, G [1 ]
机构：
[1] UNIV MESSINA,FAC MED & CHIRURG,IST MICROBIOL,I-98122 MESSINA,ITALY
来源：
INFECTION AND IMMUNITY | 1997年 / 65卷 / 06期
关键词：
D O I：
10.1128/IAI.65.6.2454-2456.1997
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-G release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor necrosis factor alpha independent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus ire monocytic cells, these findings may he clinically relevant.
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收藏
页码：2454 / 2456
页数：3
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