Regioselective Ruthenium-Catalyzed Carbonylative Direct Arylation of Five-Membered and Condensed Heterocycles

被引：27

作者：

Pospech, Jola ^{[1
]}

Tlili, Anis ^{[1
]}

Spannenberg, Anke ^{[1
]}

Neumann, Helfried ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 11期

关键词：

carbonylative coupling; CH bond functionalization; heterocycles; multicomponent reactions; ruthenium; C-H BOND; CROSS-COUPLING REACTION; DIARYL KETONES; ARYL KETONES; PHOSPHINE OXIDES; ACYL CHLORIDES; HECK REACTION; ACTIVATION; ALDEHYDES; FUNCTIONALIZATION;

D O I：

10.1002/chem.201304314

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A ruthenium-catalyzed carbonylative CH bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed. By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp(2))C(sp(2)) bond formation has been achieved. This straightforward catalytic process provides access to versatile products prevalent in multiple bioactive compounds and supplies a valuable functional group for subsequent transformations.

引用

页码：3135 / 3141

页数：7

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