Seroepidemiological study of norovirus infection in Aichi Prefecture, Japan

被引：12
|
作者：
Kobayashi, Shinichi [1 ]
Fujiwara, Noriko [1 ]
Takeda, Naokazu [2 ]
Minagawa, Hiroko [1 ]
机构：
[1] Aichi Prefectural Inst Publ Hlth, Virol Lab, Dept Microbiol & Med Zool, Kita Ku, Nagoya, Aichi 4628576, Japan
[2] Natl Inst Infect Dis, Dept Virol 2, Tokyo 2080011, Japan
来源：
MICROBIOLOGY AND IMMUNOLOGY | 2009年 / 53卷 / 06期
关键词：
norovirus; seroepidemiology; virus-like particles; NORWALK-LIKE VIRUSES; GASTROENTERITIS; RADIOIMMUNOASSAY; CALICIVIRUSES; PREVALENCE; EXPRESSION; CHALLENGE; ANTIGEN; STRAIN; ASSAYS;
D O I：
10.1111/j.1348-0421.2009.00132.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The serological prevalence of IgG antibody to seven NoV strains (GI.1, GI.4, GII.3, GII.4, GII.10, GII.12 and GII.15) among inhabitants aged 1-62 years of Aichi Prefecture, Japan was studied. Age-related seroprevalence was measured by ELISA using baculovirus-expressed recombinant VLP antigens. Seropositive rates for all seven VLP antigens gradually increased with age. Among the tested antigens, the highest seropositive rate was for the GII.4 strain. This result is consistent with the recent epidemic of NoV infection due to GII.4 strain in Japan.
引用
收藏
页码：356 / 359
页数：4
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