Sex differences in abdominal aortic aneurysms

被引:32
|
作者
Boese, Austin C. [1 ]
Chang, Lin [2 ]
Yin, Ke-Jie [3 ]
Chen, Y. Eugene [2 ]
Lee, Jean-Pyo [4 ,5 ]
Hamblin, Milton H. [1 ]
机构
[1] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA
[2] Univ Michigan, Dept Internal Med, Ctr Adv Models Translat Sci & Therapeut, Ann Arbor, MI 48109 USA
[3] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA
[4] Tulane Univ, Sch Med, Dept Physiol, New Orleans, LA 70112 USA
[5] Ctr Stem Cell Res & Regenerat Med, New Orleans, LA USA
基金
美国国家卫生研究院;
关键词
abdominal aortic aneurysm; androgen signaling; estrogen signaling; sex differences; sex steroid hormones; ANGIOTENSIN-CONVERTING ENZYME; ESTROGEN-RECEPTOR-ALPHA; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; HORMONE REPLACEMENT THERAPY; PROSTAGLANDIN E-2 SYNTHESIS; MESSENGER-RNA EXPRESSION; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; GENDER-DIFFERENCES;
D O I
10.1152/ajpheart.00519.2017
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Abdominal aortic aneurysm (AAA) is a vascular disorder with a high case fatality rate in the instance of rupture. AAA is a multifactorial disease, and the etiology is still not fully understood. AAA is more likely to occur in men, but women have a greater risk of rupture and worse prognosis. Women are reportedly protected against AAA possibly by premenopausal levels of estrogen and are, on average, diagnosed at older ages than men. Here, we review the present body of research on AAA pathophysiology in humans, animal models, and cultured cells, with an emphasis on sex differences and sex steroid hormone signaling.
引用
收藏
页码:H1137 / H1152
页数:16
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