Niizalactams A-C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing Bacterium

被引：61

作者：

Hoshino, Shotaro ^{[1
]}

Okada, Masahiro ^{[1
]}

Wakirnoto, Toshiyuki ^{[1
]}

Zhang, Huiping ^{[2
]}

Hayashi, Fumiaki ^{[2
]}

Onaka, Hiroyasu ^{[3
]}

Abe, Ikuro ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] RIKEN Ctr Life Sci Technol, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[3] Univ Tokyo, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 12期

关键词：

ABSOLUTE-CONFIGURATION; DISCOVERY; BIOSYNTHESIS; ANTIBIOTICS; METABOLITES; POLYKETIDE; OXYLIPINS; ALCOHOLS; GENOME; NMR;

D O I：

10.1021/acs.jnatprod.5b00804

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A terrestrial bacterium, Streptomyces sp. NZ-6, produced niizalactams A-C (1-3), unprecedented di- and tricyclic macrolactams, by coculturing with the mycolic acid-containing bacterium Tsukamurella pulmonis TP-B0596. Their complete structures, including absolute configurations, were elucidated on, the basis of spectroscopic data and chemical derivatization. Their unique skeletons are proposed to be biosynthesized from a common 26-membered macrolactam intermediate by S(N)2 cyclization or an intramolecular Diels-Alder reaction.

引用

页码：3011 / 3017

页数：7

共 19 条

[1] Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp and mycolic acid-containing bacterium
Hoshino, Shotaro
Wong, Chin Piow
Ozeki, Masahiro
Zhang, Huiping
Hayashi, Fumiaki
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Asamizu, Shumpei
Onaka, Hiroyasu
Abe, Ikuro
JOURNAL OF ANTIBIOTICS, 2018, 71 (07): : 653 - 657
[2] Mirilactams C-E, Novel Polycyclic Macrolactams Isolated from Combined-Culture of Actinosynnema mirum NBRC 14064 and Mycolic Acid-Containing Bacterium
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Ozeki, Masahiro
Wong, Chin Piow
Zhang, Huiping
Hayashi, Fumiaki
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Morita, Hiroyuki
Onaka, Hiroyasu
Abe, Ikuro
CHEMICAL & PHARMACEUTICAL BULLETIN, 2018, 66 (06) : 660 - 667
[3] Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium
Shotaro Hoshino
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[4] Chojalactones A-C, Cytotoxic Butanolides Isolated from Streptomyces sp Cultivated with Mycolic Acid Containing Bacterium
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[6] Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823
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[7] Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823
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[10] Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp.
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