Selective manipulation of superparamagnetic nanoparticles for product purification and microfluidic diagnostics

被引：5
|
作者：
Gaedke, Johannes [1 ,2 ,3 ]
Thies, Jan-Wilhelm [1 ,4 ]
Kleinfeldt, Lennart [1 ,5 ]
Schulze, Torben [1 ,6 ]
Biedendieck, Rebekka [3 ,7 ]
Rustenbeck, Ingo [1 ,6 ]
Garnweitner, Georg [1 ,5 ]
Krull, Rainer [1 ,2 ,3 ]
Dietzel, Andreas [1 ,4 ]
机构：
[1] TU Braunschweig, Ctr Pharmaceut Engn PVZ, Franz Liszt Str 35a, D-38106 Braunschweig, Germany
[2] TU Braunschweig, Inst Biochem Engn, Rebenring 56, D-38106 Braunschweig, Germany
[3] TU Braunschweig, Braunschweig Integrated Ctr Syst Biol BRICS, Rebenring 56, D-38106 Braunschweig, Germany
[4] TU Braunschweig, Inst Microtechnol, Alte Salzdahlumer Str 203, D-38124 Braunschweig, Germany
[5] TU Braunschweig, Inst Particle Technol, Volkmaroder Str 5, D-38104 Braunschweig, Germany
[6] TU Braunschweig, Inst Pharmacol & Toxicol, Mendelssohnstr 1, D-38106 Braunschweig, Germany
[7] TU Braunschweig, Inst Microbiol, Spielmannstr 7, D-38106 Braunschweig, Germany
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2018年 / 126卷
关键词：
Superparamagnetic nanoparticles; Downstream processing; Quartz crystal microbalance; Point-of-care diagnostics; IRON-OXIDE NANOPARTICLES; MAGNETIC NANOPARTICLES; HYDROTHERMAL SYNTHESIS; FERRITE NANOPARTICLES; SURFACE MODIFICATION; MFE2O4; M; SEPARATION; PARTICLES; MN; IMMUNOSENSOR;
D O I：
10.1016/j.ejpb.2017.09.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The needs of scalable product purification as well as the demand for sensitive diagnostics for highly dilute entities can be addressed with the utilization of tailored superparamagnetic nanoparticles. Recent developments have led to more efficient fluidic systems at different scales with suspended nanoparticles or nanoparticle aggregates. However, magnetic nanoparticle systems differ widely in properties and their applications are characterized by very specific challenges. This review summarizes advances in the synthesis of superparamagnetic particles and displays states and trends in research making use of these particles in biotechnological downstream processing and in biosensing.
引用
收藏
页码：67 / 74
页数：8
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