A case of T-lineage lymphoblastic lymphoma/leukemia with t(4;11)(q21;p15) that switched to myelomonocytic leukemia at relapse

被引：0
|
作者：
Kawakami, K
Miyanishi, S
Amakawa, R
Hayashi, T
Kurata, M
Nakamura, F
Tanaka, Y
Ohno, Y
Shiku, H
机构：
[1] Tenri Hosp, Div Hematol, Nara, Japan
[2] Mie Univ, Sch Med, Dept Internal Med 2, Tsu, Mie 514, Japan
[3] Tenri Hosp, Div Med Res, Nara, Japan
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 1999年 / 69卷 / 03期
关键词：
lineage switch; T-lymphoblastic lymphoma/leukemia t(4; 11)(q21; p15);
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 51-year-old Japanese woman, initially diagnosed with T-lineage (CD2(+), CD7(+), CD3(-), CD4(-), CD8(-)) lymphoblastic lymphoma with t(4,ll)(q21:p15), relapsed with acute myelomonocytic leukemia with the identical chromosomal abnormality. Southern-blot analysis revealed clonal rearrangements of an immunoglobulin heavy chain gene (JH) and T-cell receptor genes (J delta 1, J gamma 1, C beta 1) at fil st presentation, bur germ line configurations of these genes at relapse, Leukemias with t(4:Il)(q21:p15) may involve a hematopoietic progenitor capable of multilineage differentiation. (C) 1999 The Japanese Society of Hematology.
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收藏
页码：196 / 199
页数：4
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