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- [1] Missed polyps, missed opportunitiesGASTROINTESTINAL ENDOSCOPY, 2011, 74 (02) : 262 - 265Ananthakrishnan, Ashwin N.Chan, Andrew T.
Missed opportunities in crystallography
被引：2
|作者：
Dauter, Zbigniew
[1
]
Jaskolski, Mariusz
[2
,3
]
机构：
[1] NCI, Synchrotron Radiat Res Sect, Argonne Natl Lab, Argonne, IL 60439 USA
[2] Adam Mickiewicz Univ, Fac Chem, Dept Crystallog, PL-60780 Poznan, Poland
[3] Polish Acad Sci, Inst Bioorgan Chem, Ctr Biocrystallog Res, Poznan, Poland
关键词：
crystals;
discoveries;
history;
structural biology;
X-ray crystallography;
3-DIMENSIONAL FOURIER SYNTHESIS;
X-RAY-ANALYSIS;
MOLECULAR-STRUCTURE;
ICOSAHEDRAL SYMMETRY;
QUASI-CRYSTALS;
INTERATOMIC DISTANCES;
DIFFRACTING POWER;
KEPLER CONJECTURE;
NUCLEIC-ACIDS;
DOUBLE HELIX;
D O I：
10.1111/febs.12832
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
Scrutinized from the perspective of time, the giants in the history of crystallography more than once missed a nearly obvious chance to make another great discovery, or went in the wrong direction. This review analyzes such missed opportunities focusing on macromolecular crystallographers (using Perutz, Pauling, Franklin as examples), although cases of particular historical (Kepler), methodological (Laue, Patterson) or structural (Pauling, Ramachandran) relevance are also described. Linus Pauling, in particular, is presented several times in different circumstances, as a man of vision, oversight, or even blindness. His example underscores the simple truth that also in science incessant creativity is inevitably connected with some probability of fault.
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页码：4010 / 4020
页数：11
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