Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer

被引：208
|
作者：
Zhang, Yumin [1 ,2 ]
Yang, Cuihong [1 ,2 ]
Wang, Weiwei [2 ,3 ]
Liu, Jinjian [1 ,2 ]
Liu, Qiang [1 ,2 ]
Huang, Fan [1 ,2 ]
Chu, Liping [1 ,2 ]
Gao, Honglin [1 ,2 ]
Li, Chen [2 ,3 ]
Kong, Deling [2 ,3 ]
Liu, Qian [4 ]
Liu, Jianfeng [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Radiat Med, Tianjin Key Lab Radiat Med & Mol Nucl Med, Tianjin 300192, Peoples R China
[2] Peking Union Med Coll, Tianjin 300192, Peoples R China
[3] Chinese Acad Med Sci, Inst Biomed Engn, Tianjin Key Lab Biomat Res, Tianjin 300192, Peoples R China
[4] Tianjin First Cent Hosp, Dept Urol, Tianjin 300192, Peoples R China
来源：
SCIENTIFIC REPORTS | 2016年 / 6卷
基金：
中央高校基本科研业务费专项资金资助;
关键词：
DRUG-DELIVERY; IN-VITRO; ANTITUMOR EFFICACY; POLYMERIC MICELLES; CELLULAR UPTAKE; LIPOSOMES; HYDROGEL; CONJUGATE; RELEASE; TISSUE;
D O I：
10.1038/srep21225
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Ample attention has focused on cancer drug delivery via prodrug nanoparticles due to their high drug loading property and comparatively lower side effects. In this study, we designed a PEG-DOX-Cur prodrug nanoparticle for simultaneous delivery of doxorubicin (DOX) and curcumin (Cur) as a combination therapy to treat cancer. DOX was conjugated to PEG by Schiff's base reaction. The obtained prodrug conjugate could self-assemble in water at pH 7.4 into nanoparticles (PEG-DOX NPs) and encapsulate Cur into the core through hydrophobic interaction (PEG-DOX-Cur NPs). When the PEG-DOX-Cur NPs are internalized by tumor cells, the Schiff's base linker between PEG and DOX would break in the acidic environment that is often observed in tumors, causing disassembling of the PEG-DOX-Cur NPs and releasing both DOX and Cur into the nuclei and cytoplasma of the tumor cells, respectively. Compared with free DOX, free Cur, free DOX-Cur combination, or PEG-DOX NPs, PEG-DOX-Cur NPs exhibited higher anti-tumor activity in vitro. In addition, the PEG-DOX-Cur NPs also showed prolonged blood circulation time, elevated local drug accumulation and increased tumor penetration. Enhanced anti-tumor activity was also observed from the PEG-DOX-Cur-treated animals, demonstrating better tumor inhibitory property of the NPs. Thus, the PEG-DOX-Cur prodrug nanoparticle system provides a simple yet efficient approach of drug delivery for chemotherapy.
引用
收藏
页数：12
相关论文
共 50 条
  • [1] Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer
    Yumin Zhang
    Cuihong Yang
    Weiwei Wang
    Jinjian Liu
    Qiang Liu
    Fan Huang
    Liping Chu
    Honglin Gao
    Chen Li
    Deling Kong
    Qian Liu
    Jianfeng Liu
    [J]. Scientific Reports, 6
  • [2] Co-delivery of doxorubicin and pH-sensitive curcumin prodrug by transferrin-targeted nanoparticles for breast cancer treatment
    Cui, Tongxing
    Zhang, Sihao
    Sun, Hong
    [J]. ONCOLOGY REPORTS, 2017, 37 (02) : 1253 - 1260
  • [3] Dual Targeting pH-Sensitive Co-Delivery Curcumin and β-Elemene Nanomedicine for Breast Cancer Therapy
    Liu, Mengna
    Wu, Jun
    Wang, Kaili
    Yuan, Dehao
    Wang, Yinan
    Cheng, Haoran
    Zhao, Feng
    Fan, Huaying
    Xu, Hui
    Chen, Daquan
    [J]. SCIENCE OF ADVANCED MATERIALS, 2019, 11 (10) : 1362 - 1368
  • [4] Co-delivery of erlotinib and doxorubicin by pH-sensitive charge conversion nanocarrier for synergistic therapy
    He, Yongju
    Su, Zhigui
    Xue, Lingjing
    Xu, Hui
    Zhang, Can
    [J]. JOURNAL OF CONTROLLED RELEASE, 2016, 229 : 80 - 92
  • [5] Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy
    Jiang, Yanhua
    Zhou, Yongjian
    Zhang, Can Yang
    Fang, Te
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 15 : 3319 - 3331
  • [6] pH-Sensitive nanodiamond co-delivery of retinal and doxorubicin boosts breast cancer chemotherapy
    Cui, Jicheng
    Hu, Bo
    Fu, Yuejun
    Xu, Zhengkun
    Li, Yingqi
    [J]. RSC ADVANCES, 2023, 13 (39) : 27403 - 27414
  • [7] pH-sensitive nanocarriers for curcumin delivery in cancer therapy
    Mohammadzadeh, Vahideh
    Zirak, Mohammad Reza
    Khah, Seyedeh Maryam Hosseini
    Kamali, Hossein
    Jaafari, Mahmoud Reza
    [J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 66
  • [8] Co-delivery of doxorubicin and curcumin by a pH-sensitive, injectable, and in situ hydrogel composed of chitosan, graphene, and cellulose nanowhisker
    Omidi, Sakineh
    Pirhayati, Mozhgan
    Kakanejadifard, Ali
    [J]. CARBOHYDRATE POLYMERS, 2020, 231
  • [9] Co-delivery of NIR-II semiconducting polymer and pH-sensitive doxorubicin-conjugated prodrug for photothermal/chemotherapy
    Yu, Dongsheng
    Wang, Yazhou
    Chen, Jifeng
    Liu, Shuang
    Deng, Shaohui
    Liu, Chengbo
    McCulloch, Iain
    Yue, Wan
    Cheng, Du
    [J]. Acta Biomaterialia, 2022, 137 : 238 - 251
  • [10] Co-delivery of NIR-II semiconducting polymer and pH-sensitive doxorubicin-conjugated prodrug for photothermal/chemotherapy
    Yu, Dongsheng
    Wang, Yazhou
    Chen, Jifeng
    Liu, Shuang
    Deng, Shaohui
    Liu, Chengbo
    McCulloch, Iain
    Yue, Wan
    Cheng, Du
    [J]. ACTA BIOMATERIALIA, 2022, 137 : 238 - 251
12345