Avoidant personality disorder (AvPD) and social anxiety disorder (SAD) share risk factors to a substantial degree, and both are characterized by the experience of anxiety in social situations. The authors investigated whether these disorders are differentially related to the Big Five personality traits. They also examined the underlying genetic and environmental influences on these associations. A population-based sample of 1,761 female twins was interviewed at baseline, and 1,471 of these were re-interviewed 10 years later. Associations between AvPD, SAD, and personality traits were investigated with multivariate biometric analyses. The authors found that AvPD and SAD are differentially related to several personality traits at the phenotypic, genetic, and environmental level. The genetic and environmental liability to AvPD could be fully accounted for by the genetic and environmental factors influencing SAD and personality. The findings may increase current etiological understanding of these disorders and inform future classification and treatment efforts.
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Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
Marques, Luana
Porter, Eliora
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Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
Univ Penn, Dept Psychol, Philadelphia, PA 19104 USAMassachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
Porter, Eliora
Keshaviah, Aparna
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Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
Keshaviah, Aparna
Pollack, Mark H.
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Rush Univ, Med Ctr, Dept Psychiat, Chicago, IL 60612 USAMassachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
Pollack, Mark H.
Van Ameringen, Michael
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St Josephs Healthcare Hamilton, Dept Psychiat & Behav Neurosci, Hamilton, ON L8P 3B5, CanadaMassachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
Van Ameringen, Michael
Stein, Murray B.
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Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92037 USAMassachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
Stein, Murray B.
Simon, Naomi M.
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Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
机构:
Univ Penn, Sch Med, Ctr Treatment & Study Anxiety, Dept Psychiat, Philadelphia, PA 19104 USAUniv Penn, Sch Med, Ctr Treatment & Study Anxiety, Dept Psychiat, Philadelphia, PA 19104 USA
Huppert, Jonathan D.
Strunk, Daniel R.
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Univ Penn, Sch Med, Ctr Treatment & Study Anxiety, Dept Psychiat, Philadelphia, PA 19104 USA
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USAUniv Penn, Sch Med, Ctr Treatment & Study Anxiety, Dept Psychiat, Philadelphia, PA 19104 USA
Strunk, Daniel R.
Ledley, Deborah Roth
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Univ Penn, Sch Med, Ctr Treatment & Study Anxiety, Dept Psychiat, Philadelphia, PA 19104 USAUniv Penn, Sch Med, Ctr Treatment & Study Anxiety, Dept Psychiat, Philadelphia, PA 19104 USA
Ledley, Deborah Roth
Davidson, Jonathan R. T.
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Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USAUniv Penn, Sch Med, Ctr Treatment & Study Anxiety, Dept Psychiat, Philadelphia, PA 19104 USA
Davidson, Jonathan R. T.
Foa, Edna B.
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Univ Penn, Sch Med, Ctr Treatment & Study Anxiety, Dept Psychiat, Philadelphia, PA 19104 USAUniv Penn, Sch Med, Ctr Treatment & Study Anxiety, Dept Psychiat, Philadelphia, PA 19104 USA