Five New Alkaloids from the Stem Bark of Daphniphyllum macropodum

被引：12
|
作者：
Lu, Yunyang [1 ]
Gao, Kai [1 ]
Wang, Xiaoyang [1 ]
Zhang, Wei [1 ]
Ma, Ning [1 ]
Tang, Haifeng [1 ,2 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Inst Mat Med, Sch Pharm, Xian 710032, Peoples R China
来源：
MOLECULES | 2014年 / 19卷 / 03期
关键词：
Daphniphyllum macropodum; daphnicyclidins M and N; calyciphyllines Q-S; alkaloids; cytotoxicity; PENTACYCLIC ALKALOIDS; A-D; TRITERPENOID SAPONINS; MIQ; HUMILE; LEAVES; MOIETY; LONGERACEMOSUM; TEI[!text type='JS']JS[!/text]MANII; YUNNANENSE;
D O I：
10.3390/molecules19033055
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Five new alkaloids, daphnicyclidins M and N (compounds 1 and 2) and calyciphyllines Q-S (compounds 3-5), along with four known ones, paxiphylline C (6), macropodumine B (7), macropodumine C (8) and daphnicyclidin A (9) were isolated from the stem bark of Daphniphyllum macropodum. Calyciphylline Q (3) is the first calyciphylline A derivative possessing a double bond between C-18 and C-19. Their structures and relative configurations were elucidated on the basis of spectroscopic methods, especially 2D NMR techniques. Compounds 1, 2, 8 and 9 exhibited cytotoxic activity against P-388 cells with IC50 values of 5.7, 6.5, 10.3 and 13.8 mu M, respectively. Compounds 1 and 2 also showed cytotoxic activity against SGC-7901 cells with IC50 values of 22.4 and 25.6 mu M.
引用
收藏
页码：3055 / 3067
页数：13
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