Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study

Objective: To evaluate the preemptive analgesic effect of combination pregabalin with celecoxib for lumbar spine surgery. Methods: A prospective, randomized study was conducted among 60 lumbar spine surgery patients and divided into two groups. Postoperative pain relief was achieved with intravenous patient-controlled analgesia with morphine. The preemptive analgesia group received oral pregabalin (150 mg) and celecoxib (200 mg) 2 hrs before surgery, and the control group received a placebo. Pain was assessed by visual analogue scale (VAS). Side effects and morphine consumption were monitored until 48 hrs after surgery. Results: VAS score at rest and during movement was statistically significantly lower in the preemptive analgesia group at most time points (p<0.05). Morphine consumption was significantly lower in the preemptive analgesia group compared with control group in the 24 first hours (29.03 +/- 4.38 mg vs 24.43 +/- 4.94) and 48 hrs (52.23 +/- 9.57 mg vs 44.20 +/- 10.21 mg), p<0.05. Hemodynamics, respiratory rate, and SpO(2) were similar for both groups. The sedation score was only statistically significant at H8 time point. The incidence of nausea/vomiting in the preemptive group did not statistically differ from the control group. Conclusion: Preoperative administration of pregabalin combined with celecoxib had a good preemptive analgesia effect and reduced intravenous morphine consumption after lumbar spine surgery. Side effects were mild and transient.