Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study
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作者:
Nguyen Trung Kien
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Vietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, VietnamVietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, Vietnam
Nguyen Trung Kien
[1
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Geiger, Phillip
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Naval Med Ctr Portsmouth, Dept Anesthesiol Perioperat & Pain Med, Portsmouth, VA USAVietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, Vietnam
Geiger, Phillip
[2
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Hoang Van Chuong
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Vietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, VietnamVietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, Vietnam
Hoang Van Chuong
[1
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Nguyen Manh Cuong
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Vietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, VietnamVietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, Vietnam
Nguyen Manh Cuong
[1
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Ngo Van Dinh
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Vietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, VietnamVietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, Vietnam
Ngo Van Dinh
[1
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Dinh Cong Pho
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Vietnam Mil Med Univ, Fac Med, Hanoi, VietnamVietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, Vietnam
Dinh Cong Pho
[3
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Vu The Anh
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Vietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, VietnamVietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, Vietnam
Vu The Anh
[1
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Nguyen Truong Giang
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Vietnam Mil Med Univ, Mil Hosp 103, Dept Cardiothorac Surg, 261 Phung Hung Rd, Hanoi 100000, VietnamVietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, Vietnam
Nguyen Truong Giang
[4
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机构:
[1] Vietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, Vietnam
[2] Naval Med Ctr Portsmouth, Dept Anesthesiol Perioperat & Pain Med, Portsmouth, VA USA
[3] Vietnam Mil Med Univ, Fac Med, Hanoi, Vietnam
[4] Vietnam Mil Med Univ, Mil Hosp 103, Dept Cardiothorac Surg, 261 Phung Hung Rd, Hanoi 100000, Vietnam
Objective: To evaluate the preemptive analgesic effect of combination pregabalin with celecoxib for lumbar spine surgery. Methods: A prospective, randomized study was conducted among 60 lumbar spine surgery patients and divided into two groups. Postoperative pain relief was achieved with intravenous patient-controlled analgesia with morphine. The preemptive analgesia group received oral pregabalin (150 mg) and celecoxib (200 mg) 2 hrs before surgery, and the control group received a placebo. Pain was assessed by visual analogue scale (VAS). Side effects and morphine consumption were monitored until 48 hrs after surgery. Results: VAS score at rest and during movement was statistically significantly lower in the preemptive analgesia group at most time points (p<0.05). Morphine consumption was significantly lower in the preemptive analgesia group compared with control group in the 24 first hours (29.03 +/- 4.38 mg vs 24.43 +/- 4.94) and 48 hrs (52.23 +/- 9.57 mg vs 44.20 +/- 10.21 mg), p<0.05. Hemodynamics, respiratory rate, and SpO(2) were similar for both groups. The sedation score was only statistically significant at H8 time point. The incidence of nausea/vomiting in the preemptive group did not statistically differ from the control group. Conclusion: Preoperative administration of pregabalin combined with celecoxib had a good preemptive analgesia effect and reduced intravenous morphine consumption after lumbar spine surgery. Side effects were mild and transient.
机构:
Jian Yang Hosp Tradit Chinese Med, Dept Orthopaed, Jianyang 641400, Peoples R ChinaJian Yang Hosp Tradit Chinese Med, Dept Orthopaed, Jianyang 641400, Peoples R China
Zhou, Yi
Liu, Xiaoyan
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Zunyi Med Univ, Peoples Hosp Zunyi City 1, Dept Orthopaed, Affiliated Hosp 3, Zunyi 563000, Peoples R ChinaJian Yang Hosp Tradit Chinese Med, Dept Orthopaed, Jianyang 641400, Peoples R China
Liu, Xiaoyan
Ding, Chuan
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Zunyi Med Univ, Peoples Hosp Zunyi City 1, Dept Orthopaed, Affiliated Hosp 3, Zunyi 563000, Peoples R ChinaJian Yang Hosp Tradit Chinese Med, Dept Orthopaed, Jianyang 641400, Peoples R China
Ding, Chuan
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Xiang, Bingyan
Yan, Ling
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Zunyi Med Univ, Peoples Hosp Zunyi City 1, Dept Orthopaed, Affiliated Hosp 3, Zunyi 563000, Peoples R ChinaJian Yang Hosp Tradit Chinese Med, Dept Orthopaed, Jianyang 641400, Peoples R China
机构:
Hebei Med Univ, Cangzhou Clin Coll Integrated Tradit Chinese & Wes, Dept Orthopaed, Cangzhou 061000, Peoples R China
Qian Tong North St 17, Cangzhou 641000, Hebei, Peoples R ChinaHebei Med Univ, Cangzhou Clin Coll Integrated Tradit Chinese & Wes, Dept Orthopaed, Cangzhou 061000, Peoples R China
Shuzhang, Yao
Wang, Lue
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Hebei Med Univ, Cangzhou Clin Coll Integrated Tradit Chinese & Wes, Dept Intens Med, Cangzhou 061000, Peoples R ChinaHebei Med Univ, Cangzhou Clin Coll Integrated Tradit Chinese & Wes, Dept Orthopaed, Cangzhou 061000, Peoples R China
Wang, Lue
Ding, Kaifang
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Hebei Med Univ, Cangzhou Clin Coll Integrated Tradit Chinese & Wes, Dept Intens Med, Cangzhou 061000, Peoples R ChinaHebei Med Univ, Cangzhou Clin Coll Integrated Tradit Chinese & Wes, Dept Orthopaed, Cangzhou 061000, Peoples R China
Ding, Kaifang
Zhao, Bin
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Hebei Med Univ, Cangzhou Clin Coll Integrated Tradit Chinese & Wes, Dept Orthopaed, Cangzhou 061000, Peoples R ChinaHebei Med Univ, Cangzhou Clin Coll Integrated Tradit Chinese & Wes, Dept Orthopaed, Cangzhou 061000, Peoples R China
机构:
Univ Indonesia, Dept Orthopaed & Traumatol, Cipto Mangunkusumo Natl Cent Hosp, Jalan Diponegoro 71, Jakarta 10430, Indonesia
Univ Indonesia, Fac Med, Jalan Diponegoro 71, Jakarta 10430, IndonesiaUniv Indonesia, Dept Orthopaed & Traumatol, Cipto Mangunkusumo Natl Cent Hosp, Jalan Diponegoro 71, Jakarta 10430, Indonesia
Lubis, Andri M. T.
Rawung, Rangga B. V.
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Univ Indonesia, Dept Orthopaed & Traumatol, Cipto Mangunkusumo Natl Cent Hosp, Jalan Diponegoro 71, Jakarta 10430, Indonesia
Univ Indonesia, Fac Med, Jalan Diponegoro 71, Jakarta 10430, IndonesiaUniv Indonesia, Dept Orthopaed & Traumatol, Cipto Mangunkusumo Natl Cent Hosp, Jalan Diponegoro 71, Jakarta 10430, Indonesia