Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study

被引:18
|
作者
Nguyen Trung Kien [1 ]
Geiger, Phillip [2 ]
Hoang Van Chuong [1 ]
Nguyen Manh Cuong [1 ]
Ngo Van Dinh [1 ]
Dinh Cong Pho [3 ]
Vu The Anh [1 ]
Nguyen Truong Giang [4 ]
机构
[1] Vietnam Mil Med Univ, Mil Hosp 103, Dept Anesthesia & Pain Med, Hanoi, Vietnam
[2] Naval Med Ctr Portsmouth, Dept Anesthesiol Perioperat & Pain Med, Portsmouth, VA USA
[3] Vietnam Mil Med Univ, Fac Med, Hanoi, Vietnam
[4] Vietnam Mil Med Univ, Mil Hosp 103, Dept Cardiothorac Surg, 261 Phung Hung Rd, Hanoi 100000, Vietnam
来源
关键词
preemptive analgesia; pregabalin; celecoxib; lumbar spine surgery; POSTOPERATIVE PAIN-CONTROL; QUALITY-OF-LIFE; MULTIMODAL ANALGESIA; MANAGEMENT; INHIBITORS;
D O I
10.2147/DDDT.S202410
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Objective: To evaluate the preemptive analgesic effect of combination pregabalin with celecoxib for lumbar spine surgery. Methods: A prospective, randomized study was conducted among 60 lumbar spine surgery patients and divided into two groups. Postoperative pain relief was achieved with intravenous patient-controlled analgesia with morphine. The preemptive analgesia group received oral pregabalin (150 mg) and celecoxib (200 mg) 2 hrs before surgery, and the control group received a placebo. Pain was assessed by visual analogue scale (VAS). Side effects and morphine consumption were monitored until 48 hrs after surgery. Results: VAS score at rest and during movement was statistically significantly lower in the preemptive analgesia group at most time points (p<0.05). Morphine consumption was significantly lower in the preemptive analgesia group compared with control group in the 24 first hours (29.03 +/- 4.38 mg vs 24.43 +/- 4.94) and 48 hrs (52.23 +/- 9.57 mg vs 44.20 +/- 10.21 mg), p<0.05. Hemodynamics, respiratory rate, and SpO(2) were similar for both groups. The sedation score was only statistically significant at H8 time point. The incidence of nausea/vomiting in the preemptive group did not statistically differ from the control group. Conclusion: Preoperative administration of pregabalin combined with celecoxib had a good preemptive analgesia effect and reduced intravenous morphine consumption after lumbar spine surgery. Side effects were mild and transient.
引用
收藏
页码:2145 / 2152
页数:8
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