Straightforward synthesis of enantiomerically pure 1,2,3-triazoles derived from amino esters

被引：16

作者：

Silveira-Dorta, Gaston ^{[1
]}

Jana, Sampad ^{[1
]}

Borkova, Lucie ^{[2
]}

Thomas, Joice ^{[1
]}

Dehaen, Wim ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Chem, Mol Design & Synth, Celestijnenlaan 200F, B-3001 Leuven, Belgium

[2] Palacky Univ Olomouc, Fac Med & Dent, Inst Mol & Translat Med, Hnevotinska 1333-5, Olomouc 77900, Czech Republic

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 17期

关键词：

ACID; CYCLOADDITION; KETONES; ALKYNES; AZIDES;

D O I：

10.1039/c8ob00533h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and straightforward approach that enables, for the first time, the synthesis of enantiomerically pure 1,4,5-trisubstituted, 1,5-disubstituted, and fused 1,2,3-triazole derivatives has been developed. The synthesis employs enantiomerically pure amino esters derived from amino acids and commercially available ketones under metal-free conditions.

引用

页码：3168 / 3176

页数：9

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