Cu-Catalyzed Cross-Dehydrogenative Coupling Reactions of (Benzo)thiazoles with Cyclic Ethers

被引：141

作者：

Xie, Zengyang ^{[1
]}

Cai, Yuping ^{[2
]}

Hu, Hongwen ^{[1
]}

Lin, Chen ^{[1
]}

Jiang, Juli ^{[1
]}

Chen, Zhaoxu ^{[2
]}

Wang, Leyong ^{[1
]}

Pan, Yi ^{[1
]}

机构：

[1] Nanjing Univ, Ctr Multimol Chem, Key Lab Mesoscop Chem MOE, Nanjing 210093, Jiangsu, Peoples R China

[2] Nanjing Univ, Sch Chem & Chem Engn, Inst Theoret & Computat Chem, Nanjing 210093, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 17期

基金：

中国国家自然科学基金;

关键词：

H BOND ADJACENT; RADICAL-ADDITION; DIRECT FUNCTIONALIZATION; DIRECT ARYLATION; N-ALKYLATION; AZOLES; AMINATION; BENZOXAZOLES; ACTIVATION; OXIDATION;

D O I：

10.1021/ol4022113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed cross-dehydrogenative coupling (CDC) reactions of (benzo)thiazoles with cyclic ethers were developed under mild conditions. In particular, the formation of C-C bonds via the CDC reactions between non-benzo-fused azoles and ethers are reported for the first time. In addition, the acetals, known as the masked 2-thiazolecarboxaldehydes, could be successfully obtained by this CDC reaction. The preliminary mechanism and supportive DFT calculations are discussed as well.

引用

页码：4600 / 4603

页数：4

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