Synthesis of novel substituted tetrazoles having antifungal activity

被引：185
|
作者：
Upadhayaya, RS
Jain, S
Sinha, N
Kishore, N
Chandra, R
Arora, SK
机构：
[1] New Chem Ent Res, Div Med Chem, Pune 411042, Maharashtra, India
[2] Bundelkhand Univ, Jhansi 284128, Uttar Pradesh, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 39卷 / 07期
关键词：
antifungal activity; 5-substituted tetrazole derivatives; synthesis;
D O I：
10.1016/j.ejmech.2004.03.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In an effort to find potent antifungal agents, a variety of triazole derivatives with a 5-substituted tetrazole structure 6, 7, 12 and 14 were prepared and evaluated for antifungal activity against Candida spp., Cryptococcus neoformans, and Aspergilhis spp. in vitro. The location of the methyl group at the C-3 of compounds 12 and 14 has been demonstrated to be a key structural element of antifungal potency. (C) 2004 Elsevier SAS. All rights reserved.
引用
收藏
页码：579 / 592
页数：14
相关论文
共 50 条
  • [1] Design and synthesis of novel substituted tetrazoles as a new class of antifungal agents
    Ashour, Hayam M. A.
    Rostom, Sherif A. F.
    El Razik, Heba A. Abd
    [J]. DRUGS OF THE FUTURE, 2007, 32 : 124 - 125
  • [2] A NOVEL APPROACH FOR SYNTHESIS OF SUBSTITUTED TETRAZOLES
    Mohite, P. B.
    Pandhare, R. B.
    Khanage, S. G.
    Bhaskara, V. H.
    [J]. DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES, 2009, 4 (04) : 803 - 807
  • [3] SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME SUBSTITUTED TETRAZOLES
    WAZIR, V
    SINGH, GB
    SINGH, S
    GUPTA, R
    KACHROO, PL
    [J]. JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1991, 68 (05) : 305 - 306
  • [4] Synthesis of novel selenium and tellurium-containing tetrazoles: a class of chalcogen compounds with antifungal activity
    Libero, Francieli M.
    Xavier, Mauricio C. D.
    Victoria, Francine N.
    Nascente, Patricia S.
    Savegnago, Lucielli
    Perin, Gelson
    Alves, Diego
    [J]. TETRAHEDRON LETTERS, 2012, 53 (24) : 3091 - 3094
  • [5] A FACILE SYNTHESIS, CHARACTERISATION AND IN-VITRO ANTIINFLAMMATORY ACTIVITY OF NOVEL N-SUBSTITUTED TETRAZOLES
    Mohite, P. B.
    Bhaskar, V. H.
    [J]. JOURNAL OF OPTOELECTRONIC AND BIOMEDICAL MATERIALS, 2011, 3 (04): : 87 - 93
  • [6] Novel synthesis of 5-substituted tetrazoles from nitriles
    Koguro, K
    Oga, T
    Mitsui, S
    Orita, R
    [J]. SYNTHESIS-STUTTGART, 1998, (06): : 910 - 914
  • [7] SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME 5-SUBSTITUTED TETRAZOLES
    SHUKLA, JS
    MISRA, R
    RASTOGI, R
    [J]. CURRENT SCIENCE, 1987, 56 (14): : 709 - 710
  • [8] Study on Synthesis and Antifungal Activity of Novel Benzamides Containing Substituted Pyrazole Unit
    Wang Wei
    Wu Furan
    Ma Yidan
    Xu Dan
    Xu Gong
    [J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 42 (02) : 607 - 618
  • [9] SYNTHESIS AND ANTIFUNGAL ACTIVITY OF SOME SUBSTITUTED PYRIMIDINES
    Singh, D. N.
    Verma, N.
    Pathak, L. P.
    Shukla, P. K.
    [J]. INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 19 (03) : 229 - 232
  • [10] Synthesis of new substituted sulfonylhydrazinecarboxamides and sulfonylhydrazinecarbothioamides having antifungal and antibacterial activities
    Nalavde, YM
    Joshi, V
    [J]. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2000, 39 (01): : 76 - 79
12345