Methods for the Incorporation of Carbon-11 To Generate Radiopharmaceuticals for PET Imaging

被引：57
|
作者：
Scott, Peter J. H. [1 ]
机构：
[1] Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 33期
关键词：
carbon-11; computed tomography; PET imaging; radiochemistry; radiopharmaceuticals; POSITRON-EMISSION-TOMOGRAPHY; CLICK; F-18; RADIOTRACERS; CHEMISTRY; TRACERS;
D O I：
10.1002/anie.200901481
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Diversification to meet demand: The growing demand for novel radiopharmaceuticals can only be met through the development of new approaches to isotopic labeling. Effective strategies for 11C labeling are highlighted with emphasis on reactions with [11C]carbon dioxide and [11C] methyl iodide (see scheme). DBU=1,8-diazabicyclo[5.4.0] undec-7-ene, TMAO=trimethylamine N-oxide. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6001 / 6004
页数：4
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