The influence of ethanol on the functional status of GABAA receptors

被引：10
|
作者：
Golovko, AI
Golovko, SI
Leontieva, LV
Zefirov, SY
机构：
[1] Reg Therapeut & Diagnost Med Ctr Bekhterev, St Petersburg 198096, Russia
[2] W Virginia Univ, Morgantown, WV 26505 USA
来源：
BIOCHEMISTRY-MOSCOW | 2002年 / 67卷 / 07期
关键词：
GABA receptors; ethanol; subunits; expression;
D O I：
10.1023/A:1016354420673
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gamma aminobutyric acid (GABA) is one of the main inhibitory neurotransmitters in the mammalian brain. Its effects are realized via GABA(A), GABA(B), and GABA(C) receptors. GABA(A) is the most abundant type of GABA receptors, It consists of six classes of subunits, alpha, beta, gamma, delta, epsilon, and chi. Acute and chronic exposures to ethanol are accompanied by changes in structure and function of GABA(A) receptors. These changes may be a basis for altered behavior seen in alcoholism.
引用
收藏
页码：719 / 729
页数：11
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